Trazodone is a generic prescription medication that’s approved by the FDA to treat depression. However, it also has a variety of off-label uses. For example, trazodone can be used to treat anxiety conditions, OCD, certain chronic pain conditions and insomnia.

The following provides trazodone dosage information, including details on the differences between trazodone dosages of 50, 100 and 150 mg.

Trazodone Dosage Overview

Trazodone is available in varying dosages. Dosage begins at 50 mg and can increase to 100, 150 and 300 mg. The tablets can be divided to get a more specific, correct dosage.

Physicians will usually start patients on the lowest possible dose that will be effective. They may then increase it at intervals ranging from one to two weeks to ensure efficacy.

When someone starts taking a medication like trazodone, it can take several weeks for the drug’s full effectiveness to begin. For the treatment of depression, trazodone may start to help improve symptoms in around one to two weeks. The maximum effects may take anywhere from four to six weeks to begin.

Some of the most common side effects of trazodone include:

  • Dizziness 
  • Drowsiness
  • Dry mouth
  • Confusion
  • Constipation
  • Headache
  • Blurred vision 
  • Sexual dysfunction

Cardiac arrhythmia is also possible, particularly in people with existing heart disease.

Trazodone 50 mg

The 50 mg trazodone dosage is considered a relatively small dose. In fact, it’s the lowest dosage of the tablet that’s available. Unless the doctor orders an individual to take divided tablets, trazodone 50 mg is the smallest amount someone can take.

The starting dose used to treat insomnia is usually anywhere from 25 to 50 mg, taken close to bedtime. A doctor may increase someone’s dosage above 50 mg, but for treating insomnia, not much more than 50 mg is recommended. Higher doses can actually have the opposite effect and cause insomnia.

Trazodone 100 mg

Trazodone 100 mg is the next highest dose above 50 mg, but it’s still not a relatively high dosage on its own.

The starting dose for depression treatment is usually anywhere from 50 to 100 mg, which would be taken daily in full or divided doses. If someone experiences a lot of drowsiness with trazodone, they’re advised to take their largest dose near bedtime.

Trazodone 150 mg

The next dosage above 100 mg is trazodone 150 mg. Beyond this, the next highest dosage is 300 mg. 

Unless it’s for severe depression, patients using trazodone for depression are usually not recommended to take more than 300 mg per day. Regardless of the dose a patient starts at, their doctor may opt to increase it at regular intervals. 

Some guidelines recommend that dosages for depression treatment in adults should start at 150 mg and go up by 50 mg every few days. This may increase up to 400 mg daily in divided doses for outpatient use. For inpatient use, dosages may go up to 600 mg, divided daily.

There is also an extended-release version of trazodone. The starting dosage for this version is around 150 mg taken once a day, and it can be increased by 75 mg every few days.

Additional Trazodone Information

When trazodone is used for the treatment of insomnia, it may be taken intermittently or for short periods of time. In some cases, however, it may be used regularly.

When a trazodone dosage is given for depression, it’s recommended that patients continue using it for at least six to 12 months. Many patients may be prescribed to use it over a long-term period. The drug has relatively low long-term effects, and it can be taken with food to prevent nausea.

Once a physician feels like the appropriate response is achieved, dosages might be reduced or tapered. It is possible for people to experience a physical dependence to trazodone, which means they could experience withdrawal effects if they suddenly stop taking it. Doctors will usually create a tapering schedule to help people safely end trazodone use, particularly those who have been on the medication for a long time or take high doses.

While these are general trazodone dosage guidelines, it’s important that you rely only on the information provided to you by your doctor.

  • Sources

    Shin, Justin; Saadabadi, Abdolreza. “Trazodone.” StatPearls, February 28, 2020. Accessed May 31, 2020.

    RxList. “Trazodone.” (n.d.). Accessed May 31, 2020.

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