How Heroin Affects the Nervous System

How heroin affects the nervous system is also how it’s responsible for creating the pleasurable high people are chasing when they take the drug.

Heroin is an opioid, like prescription drugs that are so commonly abused. When someone takes an opioid including heroin, it first affects the nervous system by binding to opioid receptors. When this happens, there is a flood of dopamine that rushes into the person’s system, and that’s what’s responsible for the euphoric high.

When opioids bind to these specific receptor sites in the brain, they also control how the body perceives pain, which is why opioids are used as prescription pain medicines.

The levels of dopamine that are introduced to the body with the use of heroin are much higher than what would happen normally. In fact, there are estimates showing the level of dopamine that flood the body with heroin may be up to 10 times the amount that’s naturally produced by the body in situations involving pleasure or pain relief.

That means the sensations are much more elevated than what you could experience if your body’s natural endorphins were to bind to opioid receptors.

The key areas of the brain that are impacted by heroin are related to the reward or pleasure pathways, and they include the frontal cortex and the nucleus accumbens. These circuits are important for natural rewards such as what comes when you enjoy a meal or have sex. What this means is that if you were to do something pleasurable, such as eat, your dopamine would increase. However, with heroin, the dopamine increases are significantly amplified, and it also changes your brain’s reward pathways.

After your nervous system is consistently exposed to opioids and the subsequent elevated levels of dopamine, you adjust and develop a tolerance to heroin. This means that your threshold for pain is lowered, and your sensitivity to pain is higher. Some of these side effects may even begin as soon as after the first time you use the drug.

After you begin using heroin, your pathways that signal pain become overactive, and in this way, heroin affects the nervous system by creating the feeling that you need to keep using heroin to maintain a sense of normalcy.

Another way how heroin affects the nervous system is the fact that it depresses activity. This means it slows down vital functions of the brain and the entire nervous system, including respiration. This is what leads people to overdose from heroin.

How heroin affects the nervous system regarding being a depressant also includes the fact that it can cause a person’s heart rate to become irregular, and it can lower their body temperature and blood pressure.

So, the ways how heroin affects the nervous system that are detailed below can happen relatively quickly, but what about how heroin affects the nervous system in the long-term?

First, when you are a long-term user of heroin, it begins to affect two key areas of the brain: the prefrontal cortex and the medial temporal lobe. These are areas that are responsible for controlling memory, decision-making, self-control of social behavior, and complex thought.

Over time as you use heroin, it impacts your central nervous system which can lead to problems with rational thinking, memory, impulse control and judgment.

How heroin affects the brain in the long-term can include reduced executive functioning including impaired reasoning and problem-solving, as well as an inability to make decisions or plan for the future. People who abuse heroin may also have problems with emotional processing. The longer and heavier the abuse of heroin, the more the brain rewires itself in a way so that functioning without the drug becomes increasingly difficult, and it also becomes harder and harder not just to make decisions and show judgment but also to experience pleasure naturally without the use of drugs.

Both the short and long-term ways how heroin affects the nervous system can diminish the health and well-being of the person abusing the drug, as well as the people close to them.