Mixing aspirin and alcohol can have highly dangerous side effects.

Article at a Glance:

Several adverse side effects can occur from mixing alcohol and aspirin. These side effects include:

  • Bleeding in the stomach or intestines
  • Liver toxicity and damage
  • Increased intoxication from alcohol
  • Risk of alcohol addiction with excessive alcohol use
  • Increased aspirin in the body from the same dose

It may not be dangerous for some people to use small amounts of alcohol and aspirin together infrequently. However, if you are considering taking aspirin while drinking alcohol, you should first discuss the possible risks and side effects with your physician to see what is safe for your circumstances.

Side Effects of Mixing Aspirin and Alcohol

Several side effects can result from mixing alcohol and aspirin. Alcohol on its own affects the liver negatively and increases the risk of several kinds of liver disease. Aspirin on its own can cause liver damage, especially in higher amounts, and may also lead to an increased risk of bleeding.

When alcohol and aspirin are combined, the resulting side effects include:

  • Increased toxicity of both aspirin and alcohol
  • Increased risk of bleeding in the stomach and intestines
  • Increased risk of liver damage
  • Risk of alcohol addiction (especially with excessive alcohol use)

These side effects can be dangerous and, in the wrong set of circumstances, can be deadly.

Increased Toxicity of Alcohol and Aspirin

The liver is the organ that processes ingested substances and plays a significant role in processing both alcohol and aspirin. When both substances are used together, the liver can’t handle as much of both of them as it would be able to process if only one were used. Because of this factor, when alcohol and aspirin are used together, the amount of each substance that ends up in the blood is higher than it would be if only one were used.

The decreased ability of the liver to process alcohol and aspirin together causes a normal dose of aspirin to create increased side effects and increase the risk of toxicity, which can also lead to:

  • More alcohol from each drink ending up in the bloodstream
  • Increasing the risk of an overdose or of being impaired (from what would normally be expected)
  • Problems when driving, as the blood alcohol content will be higher from the same number of drinks

Increased Risk of Internal Bleeding

One of the possible side effects of aspirin use is the risk of bleeding in the stomach or intestines. Using alcohol and aspirin together increases this risk of bleeding. This internal bleeding could be so small that it is not possible to initially tell, but it can become life-threatening in some cases.

Increased Risk of Liver Damage

Alcohol and aspirin both stress the liver and can cause liver damage individually. It is logical, then, that mixing alcohol and aspirin increases the risk of liver damage. When these two substances are used together over a prolonged period this damage may become permanent and can lead to other complications, or even death.

If you or a loved one are struggling with an alcohol addiction or are using alcohol with other medications, even when you know it could be unsafe, then you should consider seeking professional help. The Recovery Village has helped many people overcome alcohol addiction and can connect you to the help that you need. Contact one of our team members today to learn more about how you can start on the journey to recovery.

Camille Renzoni
Editor – Camille Renzoni
Cami Renzoni is a creative writer and editor for The Recovery Village. As an advocate for behavioral health, Cami is certified in mental health first aid and encourages people who face substance use disorders to ask for the help they deserve. Read more
Benjamin Caleb Williams
Medically Reviewed By – Benjamin Caleb Williams, RN
Benjamin Caleb Williams is a board-certified Emergency Nurse with several years of clinical experience, including supervisory roles within the ICU and ER settings. Read more

National Institute on Alcohol Abuse and Alcoholism. “Harmful Interactions.” 2014. Accessed April 24, 2019.

Medscape. “Aspirin (Rx, OTC).” June 2018. Accessed April 24, 2019.

Roine, Risto et al. “Aspirin Increases Blood Alcohol Concentr[…]Ingestion of Alcohol.” Journal of the American Medical Association, November 1990. Accessed April 24, 2019.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.