Nuvigil How Long Does It Stay In Your System?

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Nuvigil is used to treat sleep disorders like narcolepsy and sleep apnea. Nuvigil has a relatively long half-life and remains in the body for at least three days. Nuvigil works by interacting with chemicals in the brain that regulate the body’s natural sleep and wake cycles. This medication is not associated with causing severe withdrawal symptoms, and many doctors advise quitting all at once. If you experience any withdrawals after stopping Nuvigil, gradually tapering off the drug should help alleviate symptoms.
Nuvigil contains the active ingredient, armodafinil, which promotes alertness. Although this medication is great for treating a variety of sleep disorders, it does have several side effects, including:

  • Dizziness
  • Headaches
  • Aniexty
  • Upset stomach
  • Nausea
  • Insomnia
  • Dry mouth
  • Diarrhea

More serious side effects associated with Nuvigil have been reported. This includes sore throat, fever, vomiting, allergic reactions, bruising, depression, changes in behavior, chest pain and heart rate changes. Contact a doctor immediately if you experience any of these severe side effects.

Nuvigil How Long Does It Stay In Your System?
The Food and Drug Administration (FDA) approved the use of Nuvigil in 2007 to treat certain sleep disorders, such as shift wake disorder, narcolepsy and apnea. This medication is also prescribed to treat depression, ADHD, jet lag and chronic fatigue. Nuvigil is not considered to be habit forming, though patients can develop a dependency over time. In these cases, individuals feel as though they cannot function without Nuvigil. Although uncommon, you may experience some withdrawal symptoms after quitting Nuvigil. This includes increased sleepiness, low energy levels and an inability to stay alert.
Nuvigil can impair cognitive functions and reaction times, depending on how long you have been taking the drug and your dosage levels. You should avoid driving or engaging in dangerous activities while taking Nuvigil, especially if you do not know how your body will react to the medication. It is not recommended to use alcohol in conjunction with Nuvigil.

Drugs to avoid while using Nuvigil include:

Nuvigil How Long Does It Stay In Your System?
Nuvigil affects the brain and body by interacting with certain neurotransmitters in the body. The drug inhibits the reuptake of chemicals, like dopamine, which are associated with regulating wakefulness and sleep cycles. This process forces the body to create more of these chemicals, which increases alertness and helps treat sleeping disorders.
Nuvigil has a half-life of around 15 hours. It generally takes three days before Nuvigil is completely out of your system, though the drug can eliminate as quickly as 2.5 days. How long Nuvigil says in your system depends on a few factors, including how long you have been taking the drug, dosage level and your overall health.
The two biggest factors that influence how long Nuvigil remains in your body are dosage levels and how long you have been taking the drug. If you have been taking Nuvigil for an extended length of time, your body will naturally build up a tolerance, which affects how fast your system eliminates it. Because of the tolerance effect, you may be prescribed higher dosages of Nuvigil daily. This also impacts how your body manages the drug. A typical dose of Nuvigil is between 150 and 250 mg daily.

Other factors that influence the length of time Nuvigil remains in the body are overall health, age and genetics. If you are not in good overall health, then your body will likely have a hard time processing and eliminating the drug. But even in the worst-case scenarios, the clear majority of Nuvigil should be out of your system within three days after the last dose.

Nuvigil only remains in the urine for anywhere between two and three days. After three days, the body has eliminated most of the drug from the system. Medications like Nuvigil typically stay in the blood and hair for longer periods. You can expect Nuvigil to appear in blood tests up to several weeks after quitting. The drug may stay in the hair for up to a month after the last dose.

If you or someone you love is struggling with substance use disorder, call 24/7 to our toll-free hotline at 855-548-9825. You can also go online to or to learn more about the road to recovery. We can help you overcome your addiction today.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.