Before a physician or care provider prescribes you any kind of medicine, they’re going to ask you about other substances you might be taking, and it’s important you answer them with honesty and give them a complete list of everything because drug interactions can be dangerous or deadly.

People frequently wonder about the potential relationship between Xanax and Zoloft, since these two drugs are both so commonly prescribed. Can Xanax and Zoloft be taken together or would this cause dangerous interactions?

The following provides information about Xanax and Zoloft separately from one another, and answers “can Xanax and Zoloft be taken together.”

Xanax and Zoloft | Can Xanax and Zoloft be Taken Together?
Before answering “can Xanax and Zoloft be taken together,” what is Xanax?

Xanax is a controlled substance in the U.S. available by prescription for the treatment of anxiety and panic disorders. Xanax works on the central nervous system by stimulating the release of the calming neurotransmitter GABA. It helps to reduce the activity of the brain, which results in the user feeling calmer and more relaxed.

Xanax is meant to be a short or intermittent treat option for anxiety and panic, for example, it could be used to treat acute panic attacks, but it shouldn’t be a long-term or regular medication that you take. Xanax can be potentially habit-forming, and you may also develop a physical dependence, meaning that if you stop using it, you go through withdrawal.

Relatively speaking Xanax reaches the brain and takes effect very quickly, but because of this, tolerance and dependence can occur pretty quickly.

The generic name of Xanax is alprazolam, and as well as being prescribed for legitimate treatments, it’s a commonly abused drug as well, that people tend to use recreationally, often when combined with other substances.

Zoloft is also a prescription drug with the generic name sertraline. It’s an antidepressant that’s part of a class of drugs called selective serotonin reuptake inhibitors or SSRIs, which balance certain chemicals in the brain. Along with helping treat the symptoms of depression, Zoloft is also used to treat panic, anxiety, and symptoms of obsessive-compulsive disorder.

People are warned against taking certain medicines with Zoloft, such as other medicines that raise serotonin levels. If you take Zoloft with another medicine that impacts serotonin, it can lead to serotonin syndrome, which can be a serious condition.

It’s important to speak with your doctor not just about other prescription medicines you take before taking Zoloft, but also herbal supplements and over-the-counter drugs.

Zoloft, like other SSRIs, takes some time before it begins to be effective. For example, for some people, it can take as long as four weeks for original symptoms to improve. Doctors warn patients not to stop taking it without their approval, even if they initially feel like it isn’t working.

Unlike Xanax, Zoloft and other SSRIs aren’t considered habit-forming, and they’re not used recreationally.

Can Xanax and Zoloft be taken together? This isn’t an uncommon question, and it wouldn’t necessarily be unusual for a person to be prescribed both Xanax and Zoloft. The reason is because the Xanax might be prescribed as a fast-acting way to cope with the symptoms of anxiety or panic, while the Zoloft would be a long-term treatment that takes longer to work, but deals with the underlying symptoms over time.

Is it safe to take Xanax and Zoloft together?

While your doctor should provide the ultimate advice, it likely is okay to take Xanax and Zoloft together. The reason is because Xanax and Zoloft work on different pathways in the brain. For example, Xanax suppresses and calms central nervous system activity, and SSRIs like Zoloft are designed to regulate serotonin levels.

While it may not be deadly to combine Xanax and Zoloft, that doesn’t mean there aren’t potential side effects. For example, if you mix Xanax and Zoloft it can lead to sedation or problems with cognition and physical function. You may have problems with thinking and coordination as an example.

There’s another potential problem that can come with taking Xanax and Zoloft together as well. You may not be able to determine how effectively the Zoloft is or isn’t working if you’re mixing it with something else like Zoloft, so you may not be able to effectively let your doctor know if you’re getting results or experiencing side effects.

To wrap it all up, can Xanax and Zoloft be taken together? They may be safe when combined, and the side effects might be minimal, such as coordination problems, but you should always speak to your doctor before taking Xanax and Zoloft at the same time.

Your doctor may have a reason that pertains to your individual health that might prevent them from saying it’s okay to take Xanax and Zoloft together, which is why you should always consult them first.

If you or a loved one develop an addiction, contact The Recovery Village® to speak to a representative about how addiction treatment can work for you.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options, and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.

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