Deciding whether combining Xanax and Prozac is right for you should be left up to your doctor. Added risks and increased side effects can occur.

Article at a Glance:

  • Prozac is the brand name for fluoxetine, an antidepressant that can be used for multiple mental health conditions.
  • Xanax is the brand name for alprazolam, a benzodiazepine that can be used for anxiety and panic disorder.
  • Your doctor may prescribe you both medications together, especially if you are new to taking Prozac.
  • Combining an antidepressant and benzodiazepine at the beginning of treatment can sometimes lead to better results than one drug alone.

Can You Take Prozac and Xanax Together?

You may be able to take Prozac and Xanax at the same time, but you should do so with caution and only while following the instructions of your doctor.

Xanax and Prozac treat similar mental health conditions, including panic disorder. If you’re taking them both for panic disorder, you should be aware that Xanax is a short-term treatment while Prozac is a long-term medication. This means that if you’re taking Prozac, you may be able to discontinue your Xanax; over time, Prozac should be effective at treating symptoms for which you previously might have used Xanax.

For some people, it may be that taking Xanax and Prozac together, at least for a period of time, does give them better outcomes than taking one of those medicines alone. Research has shown that when someone starts an antidepressant like Prozac, adding a benzodiazepine like Xanax helps people respond to their treatment protocol more quickly than they might if they just used one or the other.

The decision as to whether a combination treatment approach using Xanax and Prozac is right for you should be left up to your doctor.

What Are the Risks of Taking Prozac and Xanax Together?

While it may be okay to use Xanax and Prozac together, combining the two substances can cause the Xanax to stay in your system longer or have higher concentrations in your blood. When this happens, symptoms can include excessive drowsiness.

Doctors are careful when prescribing Prozac to younger people because it can lead to suicidal thoughts or tendencies, and anyone who starts taking it is advised to monitor their mood and other possible side effects.

It’s also important for people to tell their doctor about any other medicines, over-the-counter or prescription, as well as supplements or vitamins they may be taking. The reason is that Prozac may interact with other medicines. For example, if you took Prozac with another medicine that increases serotonin levels in the brain like an antipsychotic, it can lead to a very serious condition called serotonin syndrome.

What Is Prozac (Fluoxetine)?

Prozac is also known by the generic name fluoxetine, and it’s classified as a selection serotonin reuptake inhibitor or an SSRI. It’s an antidepressant, and it works to balance certain chemicals in the brain. Some characteristics of Prozac include:

Generic nameFluoxetine
Conditions it can treatMajor depressive disorder, Obsessive-compulsive disorder, Premenstrual dysphoric disorder, Bulimia nervosa, Anorexia nervosa, Panic disorder, Bipolar disorder
Obesity, Cataplexy (overwhelming drowsiness), Alcohol dependence, Muscle spasm, Premature ejaculation
Drug typeAntidepressant (SSRI)
Controlled substance statusNot a controlled substance
Side effectsAnxiety, nervousness, trouble sleeping, sleepiness, lack of energy, tremor, appetite loss, nausea, indigestion, diarrhea, dry mouth, decreased sex drive, abnormal ejaculation, impotence, rash, sweating, abnormal dreams, flu, inflammation of the pharynx, inflammation of the sinuses, yawning
How long it takes to have its peak effectWithin five weeks
How often to take itOnce daily


Is Prozac a benzo?

Prozac is not a benzodiazepine. It is a selective serotonin reuptake inhibitor (SSRI) antidepressant.

Does Prozac feel like Xanax?

While Prozac and Xanax have some side effects in common, like sleepiness, overall, they have different side effect profiles.

What Is Xanax (Alprazolam)?

Xanax is a Schedule IV controlled substance in the U.S. available by prescription to treat anxiety and panic disorders. Xanax works on the central nervous system by stimulating the release of the calming neurotransmitter GABA. It helps reduce the activity of the brain, which results in the user feeling calmer and more relaxed.

Some characteristics of Xanax include:

Generic nameAlprazolam
Conditions it can treatGeneralized anxiety disorder and Panic disorder
Drug typeBenzodiazepine
Controlled substance statusSchedule IV controlled substance
Side effectsSleepiness, lightheadedness, dry mouth, coordination problems, impaired memory, confusion, decreased libido
How long it takes to have its peak effectOne to two hours
How often to take itExactly as your doctor prescribes, generally one to three times daily

Prozac and Xanax Interaction

Because Prozac can increase the levels of Xanax in your system and may make Xanax last longer in your body, Xanax’s side effects may be intensified. This includes feeling excessively sleepy.

Summing Up — Xanax and Prozac

It may be fine to take Xanax and Prozac together. There aren’t necessarily any significant risks known with using the two together. That said, both Xanax and Prozac are serious medications that impact chemicals and functionality in your brain, so doing anything without following your doctor’s instructions can be dangerous.

You should also be careful when you first start using Xanax and Prozac and carefully monitor any symptoms you might be experiencing so you can let your physician know.

Xanax is a controlled substance because it is addictive. If you or a loved one develop a Xanax addictioncontact The Recovery Village to speak to a representative about how addiction treatment can work for you. The Recovery Village personalizes treatment programs to fit every patient’s needs, ensuring that their addiction and any co-occurring mental health disorders are addressed in a safe and supportive environment. Begin your journey toward a healthier future today.

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Editor – Melissa Carmona
Melissa Carmona puts years of writing and editing experience to work helping people understand substance abuse, addiction and mental health disorders. Read more
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Medically Reviewed By – Dr. Jessica Pyhtila, PharmD
Dr. Jessica Pyhtila is a Clinical Pharmacy Specialist based in Baltimore, Maryland with practice sites in inpatient palliative care and outpatient primary care at the Department of Veteran Affairs. Read more

Cochrane Common Mental Disorders Group. “Antidepressants plus benzodiazepines for[…]ith major depression.” Cochrane Library, June 3, 2019. Accessed October 18, 2021. “Xanax.” September 1, 2021. Accessed October 18, 2021. “Fluoxetine.” February 5, 2021. Accessed October 18, 2021. “Drug Interaction Report.” Accessed October 18, 2021.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.