Valium belongs to the benzodiazepine drug class and is primarily used to treat anxiety. Valium acts by affecting neurotransmitters (chemicals released to facilitate nerve communication) in the brain by suppressing the nerve activity in both the brain and the spinal cord. Valium works fast, delivering its effects in thirty to sixty minutes. It is most commonly prescribed to treat anxiety and seizure disorders, but it is also used for muscle relaxation and in anesthesia. Common side effects include dizziness, depression, disorientation, sedation, aggression, irritability, and tiredness.


Vicodin is an opioid painkiller that contains a combination of hydrocodone and acetaminophen. Vicodin is commonly used for relieving pain that stems from injuries or surgery. Common side effects of Vicodin include confusion, slowed breathing, dizziness, impaired judgment, profound drowsiness, nausea, constipation and loss of consciousness.

Valium and Vicodin in Combined Use

Valium and Vicodin are sometimes consumed together either by a miscalculation made by a physician or through a patient’s misguided effort to speed up or enhance the effects of the drugs. This combination is a dangerous occurrence since the interaction of benzodiazepines and opioid medications can result in coma or death. According to the U.S. Food & Drug Administration (FDA), the combination of these drugs can adversely affect an individual by depressing their breathing. Despite information and resources that are available to healthcare professionals, it is clear that providers routinely prescribe opioids and benzodiazepines at the same time and are unaware of the potential risks, including overdose. In a review conducted by the FDA, the results showed that these drugs are frequently prescribed together by the same healthcare provider on the same day, with a 41 percent increase of these prescriptions between 2002 and 2014.

In an interview with CBS News, Baltimore Health Commissioner Dr. Leana Wen stated that “nearly one in three unintentional overdose deaths from prescription opioids also involve benzodiazepines.” According to the Centers for Disease Control (CDC), more people died from prescription overdoses in 2014 than in any year previously.

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Editor – Thomas Christiansen
With over a decade of content experience, Tom produces and edits research articles, news and blog posts produced for Advanced Recovery Systems. Read more
Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.