Immediate-release formulations typically contain significantly less of the drug, making them harder to overdose on when taken as prescribed. Oramorph and other extended-release versions of morphine carry a high overdose potential due to the higher drug content. Oramorph is classified as a Schedule II substance by the Federal Drug Administration due to its addictive potential and high overdose rates.
The amount of Oramorph necessary to overdose depends on the unique metabolism of each patient. Some individuals are genetically or circumstantially predisposed to being tolerant to higher doses. Other patients may be hypersensitive and experience an overdose following the initiating treatment.
Severely decreased level of consciousness is different from extreme fatigue. Although early signs of an impending overdose may present as lethargy, significantly decreased levels of consciousness present as somnolence that rapidly progresses to stupor, fainting, and coma.
So long as Oramorph is taken as prescribed, the likelihood of overdose is influenced by several factors. These include the patient’s age, weight, body fat percentage, genetic tendencies, opioid tolerance, liver or kidney health, and overall physical status. Age is a factor because elderly patients tend to have slower metabolisms.
The liver is the organ that’s primarily responsible for processing Oramorph. Patients with poor liver function have a higher risk of overdose. When the liver is impaired, it can take longer to eliminate the drug, leading to elevated plasma concentrations and opioid toxicity.
In general, smaller patients have a higher likelihood of overdose when taking high doses compared to larger patients. Opioid tolerance plays a significant role in overdose tendency as well. Individuals who are already opioid-tolerant from consistent opioid use are more likely to be able to handle high doses of Oramorph.
If you or someone you love is struggling with opioid misuse, The Recovery Village is here to help.
Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.
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