How Long Does Naltrexone Stay in Your System?
Naltrexone is a generic, opioid antagonist prescription drug. It’s available under several brand names, including Revia, Vivitrol and Depade. Revia is a 50 mg tablet. Depade is another oral form of naltrexone. Vivitrol is an extended-release injectable version of naltrexone. Vivitrol is given once a month to prevent relapse for people who are addicted to alcohol or opioids. Vivitrol must be administered by a medical professional, unlike Revia and Depade -which can be taken like any other medication. Vivitrol is highly controlled, compared to Revia and Depade. All of these drugs are used as part of medication-assisted treatment (MAT) programs that address addiction and dependence. Any form of naltrexone is an opioid antagonist. This means naltrexone can block the effects of opioids when someone uses them while taking one of these drugs. Naltrexone medications can also reduce opioid and alcohol cravings, which can help people successfully complete an addiction treatment program. Naltrexone can be taken daily, several times a week, or monthly with the injection.

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Certain factors can influence how long naltrexone stays in the system. One is age. Older people tend to take longer to eliminate drugs from their system compared to younger people. A patient’s overall health and any chronic illnesses can also influence how long naltrexone stays in the system. People with a faster metabolism will eliminate naltrexone more quickly than someone with a slower metabolism. Other individual factors that influence how long naltrexone stays in the system can include body mass and hydration levels.
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There are instances in which someone might be tested by their doctor to ensure that they’re taking naltrexone as instructed. In these cases, patients may wonder how long naltrexone stays in the urine, hair and blood. When taking immediate-release versions of naltrexone, the drug can be detected in urine for about 4 to 6 hours. A blood test can show most versions of oral naltrexone for up to 24 hours, and a saliva test can show naltrexone for up to a day. In a hair follicle test, naltrexone can be present for up to 90 days. Vivitrol can show up in drug tests for months after it’s administered.
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Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.
Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help.
Your call is confidential, and there's no pressure to commit to treatment until you're ready. As a voluntary facility, we're here to help you heal -- on your terms. Our sole focus is getting you back to the healthy, sober life you deserve, and we are ready and waiting to answer your questions or concerns 24/7.
Speak to an Intake Coordinator now.352.771.2700