Naltrexone Signs, Symptoms and Side effects
What is Naltrexone?
Naltrexone is a drug that has shown great promise in assisting people recovering from addiction. Naltrexone is a unique drug that is classified as an opioid antagonist. It binds to opioid receptors in the body and blocks them from creating the high sought by people addicted to opioids. In fact, a person attempting to get high on an opioid while on naltrexone will experience no high at all. As a result, the hope is that since there is no euphoric high, the person recovering from addiction will be better able to control his or her craving for the drug. Similar drugs, like methadone and buprenorphine, are also used to assist recovering opioid addicts, but they actually activate, rather than suppress, opioid receptors.
Naltrexone comes in two forms: the pill form is called ReVia, and the monthly injection of naltrexone is called Vivitrol. The injection must be given by a physician. In either form, it is virtually impossible to obtain any type of high from naltrexone. It’s not an opioid. However, naltrexone’s ability to block or inhibit those effects is not limitless, and some people may take a higher dose of a drug or ingest more alcohol to surpass the naltrexone barrier and obtain the sought-after high; many people who have done this have overdosed as a result.

- Upset stomach or vomiting
- Diarrhea
- Headache
- Nervousness
- Sleep problems/tiredness
- Joint or muscle pain
In addition to these physical side effects, there are some psychological side effects to be aware of. These include confusion, anxiety, depression, insomnia, paranoia, euphoria, abnormal thinking, and hallucinations. These side effects are undoubtedly difficult to bear when combined with the side effects of withdrawal and possibly even post-acute withdrawal syndrome. As such, they must be closely managed by a counselor or other mental health professional.
Additionally, although naltrexone is generally regarded as safe for long-term use, there are a few long-term side effects of naltrexone (e.g., arthritis, liver damage and respiratory infections).
If you or a loved one is struggling with substance abuse or an addiction and is considering using naltrexone to overcome it, we invite you to contact our compassionate and well-trained team at The Recovery Village. We’re here to answer your questions and ready to help in any way we can.
Have more questions about Naltrexone abuse?
Read the most frequently asked questionsSeeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help.
Your call is confidential, and there's no pressure to commit to treatment until you're ready. As a voluntary facility, we're here to help you heal -- on your terms. Our sole focus is getting you back to the healthy, sober life you deserve, and we are ready and waiting to answer your questions or concerns 24/7.
Speak to an Intake Coordinator now.352.771.2700