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The effects of Modafinil are long-lasting compared to other medications. The half-life of Modafinil ranges from 12 to 15 hours, although the metabolism of Modafinil can be affected by several factors, including genetic predispositions, kidney and liver health.
Allergy and hypersensitivity are the only contraindications to using Modafinil. Scientists are still trying to understand precisely how Modafinil achieves its effects. Modafinil targets several neurotransmitters, including dopamine and norepinephrine.
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Modafinil is widely used by various branches of the armed forces across multiple countries. The United States Air Force prescribes Modafinil to its pilots to stay alert during long missions. Modafinil is a significant improvement to the use of amphetamines, which were commonly prescribed to pilots before the introduction of Modafinil. The French Foreign Legion, the United Kingdom’s Ministry of Defense and astronauts aboard the International Space Station all take Modafinil to combat sleep deprivation.
Researchers know that one of the ways Modafinil functions is by selectively inhibiting the reuptake of dopamine. Modafinil is very specific as to which dopamine transporter channels is inhibited. The reuptake of dopamine activates the release of orexin neuropeptides and histamine in certain areas of the brain, which in turn contribute to heightened arousal. Modafinil also acts on norepinephrine in the hypothalamus and on serotonin in the amygdala and frontal cortex.
Modafinil and modafinil acid can be tested for in plasma, serum and urine. Modafinil is not usually tested for in routine drug screenings. Modafinil use is unlikely to cause false positives for stimulants such as amphetamines. Instrumental techniques using liquid chromatography or gas are employed to test for Modafinil is cases of automobile accidents and post-mortem analysis. If you or a loved one needs further support managing Modafinil treatment, contact The Recovery Village anytime toll-free at 844-261-0347.