Combining Methadose and alcohol can lead to life-threatening side effects. The primary risk factor for Methadose use is severe respiratory depression. Mixing Methadose with other central nervous system depressants such as alcohol can greatly increase the risk of severe respiratory depression.

Methadose should not be mixed with these substances without first gaining doctor approval. Interactions with central nervous depressants and other drugs can lead to clinically significant respiratory depression, profound sedation, and coma. Avoid using Methadose concurrently with anxiolytics, neuroleptics, sedatives, hypnotics, and other opioids. Sedative/hypnotics like benzodiazepines are frequently involved in deaths associated with methadone products.

Common side effects of Methadose use include sedation, flushing of the skin, heat tolerance, weakness, diarrhea, excessive perspiration, dizziness, chronic fatigue, insomnia, trouble staying asleep, dry mouth, hypotension (low blood pressure), nausea, vomiting, constricted pupils, confusion, headache, seizures, and abnormal heart rhythms. Other side effects may include hallucinations, light-headedness, fainting, weight gain, stomach pains, loss of appetite, mood fluctuations, blurred vision, and decreased libido.

What is Methadose?

Methadose is s central nervous system depressant. It acts on opioid receptors in the body to reduce the patient’s perception of pain. It is commonly used in the management of opioid dependence and substance misuse. Methadose has a slow onset and is particularly long-acting. It can take up to five days of regular use before Methadose begins to reach maximum effects.

In individuals with normal liver function, Methadose can remain effective for between 8 and 36 hours. This makes it ideal for managing drug cravings while gradually weaning the patient off opioids. Patients can take a single dose, once a day to effectively manage drug cravings. For many patients with a history of severe opioid dependence, they will continue taking Methadose or an equivalent synthetic opioid for the rest of their lives.

Mixing Alcohol and Methadose

Methadose acts directly on the brain stem, the area of the brain that regulates autonomic breathing. Methadose inhibits the brain stem’s ability to regulate breathing. Under normal circumstances, the brain stem triggers respiration when carbon dioxide levels in the blood become elevated. Methadose disrupts the brain stem from interpreting electrical signals and accurately responding to fluctuating carbon dioxide concentrations.

When Methadose is combined with other central nervous system depressants, including alcohol, breathing can become inadequate. In the event of an overdose, the compounded effects of alcohol and Methadose can lead to critical organ failure, including circulatory shock and pulmonary edema. The result, if left untreated, is coma and death.

Summing Up Side Effects, Interactions, and Blackouts of Mixing Alcohol and Methadose

Methadose is a highly addictive and potentially dangerous substance. Concomitant use of Methadose with other central nervous depressants such as alcohol can lead to potentially life-threatening side effects. Signs of overdose include severe respiratory depression, pinpoint pupils, and severely decreased level of consciousness. Methadose is especially dangerous to mix with benzodiazepines like Xanax.

If you or someone you love is struggling with drug or alcohol dependency, The Recovery Village is available to answer any questions you may have.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.