Marijuana and Zoloft Interactions, Effects, & Reactions

When you take a prescription medication, particularly one that’s intended for long-term use, it’s important to be aware of any possible interactions, effects, and reactions that may come with its use. One example of a long-term medication that’s commonly prescribed is Zoloft.

Zoloft is a prescription anti-depressant, and people frequently wonder how it might interact with other substances or what the potential side effects may be.

Below is more information about one substance in particular: marijuana. There are details about the possibility of marijuana and Zoloft interactions, effects & reactions.

Marijuana and Zoloft Interactions, Effects, & Reactions

Before reviewing marijuana and Zoloft interactions, effects & reactions, what is Zoloft?

Zoloft is a prescription medicine that’s primarily used to treat depression, but it has other uses as well. The generic name is sertraline hydrochloride, and it’s a selective serotonin reuptake inhibitor or an SSRI.

The way Zoloft and other SSRIs work is by balancing the level of available serotonin in the brain, which improves mood. They can also help with sleep problems and boost energy levels.

Zoloft can also be used to treat anxiety and panic disorders, as well as compulsive behaviors. In some people, Zoloft may be used to treat post-traumatic stress disorder and premenstrual dysphoric disorder.

When someone is first prescribed Zoloft, the doctor will likely start them on the lowest possible dose that will treat symptoms but minimize side effects, and over time the dose may be adjusted as needed.

Some of the common side effects of Zoloft can include nausea, vomiting, diarrhea, nervousness, dizziness, sexual problems, weight gain or weight loss. Zoloft tends to be more likely than other SSRIs to cause diarrhea. In younger people, Zoloft may create severe side effects such as suicidal tendencies.

Zoloft and many other SSRIs may interact with other drugs such as MAOIs, so it’s important when your doctor is talking to you about taking this medication that you let them know if you take any prescription drugs, as well as any over-the-counter medicines or herbal supplements you might take.

So, what about marijuana and Zoloft interactions, effects & reactions?

People may use marijuana for a variety of reasons, including recreationally or as a way to treat a certain medical condition. It’s legal for medical use in many states, and recreationally in a few. While marijuana is believed to be less dangerous than a lot of other drugs, that doesn’t mean there aren’t possible side effects.

So what should be known about marijuana and Zoloft interactions, effects & reactions?

The first thing to know in terms of marijuana and Zoloft interactions, effects & reactions is that if you mix the two, it can lead to a higher concentration of Zoloft in your blood. This is similar to what happens when you combine antidepressants and grapefruit, which doctors advise against. If you have a higher amount of Zoloft in your blood, it can cause more significant side effects, similar to what would happen if you took a higher dose of the medicine than what was prescribed.

It’s also possible that if you have high levels of Zoloft in your blood, it can increase your risk of serotonin syndrome, which can have uncomfortable or even deadly symptoms in some cases.

There has been antidotal evidence of people mixing marijuana and Zoloft experiencing panic attacks as well, but this can be a side effect of marijuana on its own in some people. Zoloft on its own can also lead to anxiety and nervousness in some people, so it stands to reason that if you combine marijuana and Zoloft, this can be a bigger risk.
With marijuana and Zoloft interactions, effects & reactions you may also have more pronounced mild side effects, such as more drowsiness.

Finally, another thing to bear in mind if you’re researching marijuana and Zoloft interactions, effects and reactions is the fact that first, how you will react to one or both substances can be difficult to predict. People react differently to both marijuana and Zoloft, so it can be risky to combine them because you have no real way of knowing exactly what the effects will be.

It can also be difficult to determine if the Zoloft is working when you’re also using marijuana. It may make the Zoloft appear less effective when in reality it’s the marijuana and Zoloft interactions, effects & reactions you’re experiencing. Your doctor will likely recommend that you abstain from the use of marijuana particularly when you’re first prescribed Zoloft, so they will be able to determine how well it’s working to treat your symptoms.

Marijuana and Zoloft interactions, effects & reactions may be mild, and current information is based primarily on antidotal evidence, but it’s still important to speak with your doctor and also to try and avoid mixing the two if possible.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.