Lortab and alcohol are both strong substances that can affect your behavior.

They also have individual side effects that are intensified when the two are used together.

On its own, Lortab can be an effective medication. However, when it’s misused or combined with alcohol, it can become dangerous. The main ingredients in Lortab can increase your risk for the nervous system and liver damage, a hazard that is only compounded by the presence of alcohol.

Article at a Glance:

  • Lortab contains hydrocodone (an opioid) and acetaminophen (a non-opioid)
  • Negative effects of hydrocodone are enhanced by alcohol
  • Both acetaminophen and alcohol can damage the liver
  • Using Lortab and alcohol can increase the negative effects of both substances
  • It is important to avoid using Lortab with alcohol because of the risk of liver damage, cognitive difficulties, and other serious consequences

Effects of Mixing Lortab and Alcohol

Alcohol use is common in the United States. Many people incorporate drinking alcohol into their daily routine. However, if you are taking Lortab to manage pain, it is best to avoid consuming alcohol as the two together can have negative effects. Some of the side effects of combining Lortab and alcohol use include:

  • Breathing problems
  • Drowsiness
  • Dizziness
  • Weakness
  • Memory loss
  • Slurred speech
  • Loss of consciousness
  • Impaired coordination
  • Weak pulse
  • Constipation
  • Difficulty urinating
  • Heart palpitations
  • Liver damage


On its own, Lortab can be habit-forming. Alcohol is also addictive, so using the two substances together can create a cycle of dependence that is dangerous to those with a personal or family history of substance use disorder.

The individual cognitive and physical effects of alcohol and Lortab are heightened when they are combined. One of the most significant health risks is the potential for the nervous system and liver damage. Because Lortab contains both acetaminophen and hydrocodone, excessive use can harm the liver. Alcohol can also cause liver problems, even when used alone, so it is important to avoid combining the two substances

Misusing Lortab and alcohol can pose serious health risks, including overdose and alcohol poisoning. If you or someone you know needs help with a prescription drug or alcohol addiction, it is important to reach out for help before the situation becomes more dangerous.

Alcohol poisoning can be fatal. If you suspect someone is experiencing alcohol poisoning, call 911 immediately. Do NOT be afraid to seek help. If you do not have access to a phone contact Web Poison Control Services for online assistance.

If you or a loved one live with an addiction to Lortab or alcohol, treatment options are available. Addiction is a deadly medical risk that affects millions of Americans. If you’re ready to secure your health, contact The Recovery Village today to speak to a representative about how addiction treatment can help you. By addressing substance use disorders and co-occurring mental health disorders, The Recovery Village’s treatment plans can help people achieve a healthier future.

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Editor – Thomas Christiansen
With over a decade of content experience, Tom produces and edits research articles, news and blog posts produced for Advanced Recovery Systems. Read more
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Medically Reviewed By – Christina Caplinger, RPh
Christina Caplinger is a licensed pharmacist in both Colorado and Idaho and is also a board-certified pharmacotherapy specialist. Read more

Dailymed. “Lortab (syrup).” November 2018. Accessed April 28, 2019.

National Institutes of Health. “Hydrocodone.” October 30, 2018. Accessed May 1, 2019.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.