Hysingla ER (Hydrocodone) Overdose
Hysingla ER is unique from other hydrocodone formulations in two primary ways. First, it’s not a combination drug. Hydrocodone is most often combined with ibuprofen or acetaminophen or brand-name drugs like Vicodin. Hysingla is only hydrocodone. Another unique element of Hysingla is that it has misuse-deterring features. Extended-release opioids are often misused when people crush or dissolve them to snort or inject the drug. This delivers a powerful, rapid effect because all of the medication intended to be released gradually is released all at once. Hysingla ER is designed to be difficult to crush or dissolve. Unfortunately, even with certain measures to lower the risk of misuse, it is still possible.

Despite the anti-misuse protections built into Hysingla ER, you can overdose on this drug. One of the biggest risk factors for overdosing on Hysingla ER is taking it in ways other than how it’s intended to be used. For example, crushing it and snorting it or dissolving it and injecting it are the most common ways for someone to overdose on Hysingla. As was touched on above, this happens because the full potency of the drug is then released into the system of the patient all at once, as opposed to in a controlled way over 24 hours. Other Hysingla overdose risk factors can include mixing it with other central nervous system depressants. Central nervous system depressants include alcohol, benzodiazepines, tranquilizers and prescription sleep aids. Even when Hysingla is taken as prescribed but combined with other CNS depressants, it can cause an overdose.
Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help.
Your call is confidential, and there's no pressure to commit to treatment until you're ready. As a voluntary facility, we're here to help you heal -- on your terms. Our sole focus is getting you back to the healthy, sober life you deserve, and we are ready and waiting to answer your questions or concerns 24/7.
Speak to an Intake Coordinator now.352.771.2700- Low blood pressure
- Problems breathing
- Slowed, labored breathing
- Shallow breathing
- No breathing
- A bluish tint to lips and fingernails
- Nodding off
- Gurgling or snoring sounds
- Nonresponsive
- Loss of consciousness
- Clammy skin
- Muscle weakness or limpness
- Faint heartbeat
- Paleness of the skin
It’s so important for people to know the signs and symptoms of an opioid overdose. Even if only one symptom is occurring, emergency medical care should be sought immediately. It’s also important to realize not all overdoses look the same. It’s always best to show an abundance of caution when opioids are involved, prescription or otherwise. If someone is overdosing on Hysingla or another opioid, there is a medication called naloxone, which is a rapid reversal drug for opioids. As an opioid antagonist, when it’s used it effectively, it knocks opioid drugs out of the receptor sites. When someone has overdosed on a prescription opioid like Hysingla, naloxone can help their breathing return to normal. Regardless, emergency medical care is still needed, however. Without emergency help, if someone overdoses on Hysingla, they may suffer from brain damage or death.
The Recovery Village is here to help people who struggle with opioids or other drugs discover what recovery can bring to their life and the life of their loved ones. Learn more by contacting us.
Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.
Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help.
Your call is confidential, and there's no pressure to commit to treatment until you're ready. As a voluntary facility, we're here to help you heal -- on your terms. Our sole focus is getting you back to the healthy, sober life you deserve, and we are ready and waiting to answer your questions or concerns 24/7.
Speak to an Intake Coordinator now.352.771.2700