Hysingla is a medication that’s supposed to be prescribed to patients to take once every 24 hours for the relief of severe, ongoing pain. Hyslinga ER is not supposed to be prescribed as an as-needed pain medication. Hysingla ER is intended to be reserved for patients who can’t use alternative medication options, such as immediate-release opioids or non-opioid pain medicines. Hyslinga ER is a brand-name drug. The generic, active ingredient in Hyslinga is the opioid pain reliever hydrocodone. Hydrocodone is a powerful opioid, also called a narcotic. Hydrocodone is often used in combination with medications where acetaminophen is also an active ingredient. Hyslinga ER is unique because it’s a single drug formulation, and it also has misuse-deterrent features.
Hyslinga is a Schedule II controlled substance in the U.S., or rather the active ingredient hydrocodone is. Most opioids are Schedule II drugs in the U.S., according to guidelines of the DEA. Being a Schedule II controlled substance indicates the DEA sees hydrocodone as having a high misuse potential, and it can lead to severe psychological and physical dependence. With extended-release opioids, people will misuse them by crushing them, chewing them or dissolving them to get all of the effects of the medication at one time. Hyslinga is formulated to be very difficult to crush, and when it’s dissolved, it turns into a gel that’s challenging to inject. Despite those precautions, there is still a misuse potential associated with Hyslinga. Possessing or using Hyslinga without a prescription is illegal as well.
Hydrocodone is one of the drugs that’s part of the nation’s opioid epidemic. Hydrocodone can relieve pain ranging from moderate to severe. In some cases, hydrocodone is used for the treatment of post-operative pain, and it can also be used for conditions like arthritis or cancer pain. Hydrocodone is derived from the naturally-occurring opioid codeine. Hydrocodone is frequently prescribed in brand-name combination drugs such as Vicodin, Lortab, Lorcet and Norco. These are often misused and are very widely available. Combination hydrocodone formulations include either ibuprofen or acetaminophen. Along with Hysingla ER, the other brand-name extended-release version of hydrocodone is called Zohydro ER.
Oxycodone binds to opioid receptors, which are located throughout the central nervous system and the body. When Hysingla binds to those receptors, it changes pain signals and sensations, delivering powerful relief from pain. At the same time, Hyslinga also slows down the central nervous system. Someone who uses Hyslinga ER might experience feelings of euphoria, particularly if they misuse it or use high doses. Patients of Hyslinga ER may also experience relaxation or drowsiness. Other physical effects of Hyslinga ER can include nausea, vomiting, itchiness, dizziness and severe cases, and respiratory depression.
The half-life of any drug is a measure of how long it takes for half the concentration of the substance to leave the system of the patient. Based on that, it usually takes a drug around five half-lives to fully leave a patient’s system after it’s ingested. The half-life of Hyslinga HR is usually anywhere from seven to nine hours on average. Within 35 to 45 hours, most of the drug will leave the system of the average patient. Hyslinga ER is a unique opioid formulation because a steady state concentration is reached in patients prescribed this treatment around three days after they start using it. Immediate-release formulations have a shorter half-life than Hysingla ER.
Even though an average half-life range can give an estimate for how long a drug stays in the system of a patient, it’s not the full picture. There are a lot of factors that play a role in the specific time it takes a drug to be excreted fully. Some of the factors that influence how long Hysingla ER stays in your system include:
- Liver and kidney function — impairment of the liver or kidney function can mean it takes longer for someone to excrete these drugs from their
- Metabolism — usually someone with a faster metabolism is going to excrete drugs more quickly than someone with a slow metabolism.
- Dosage — a higher dosage is going to take longer to leave the system fully.
- How long someone has used opioids — opioids can accumulate in the system of the patient, so someone who has been using it for a long time may have more drug concentration in the body, and elimination time would be longer.
- Age — elderly people will almost always have a longer drug elimination time than a younger person if all other factors are the same.
- Other drugs — if other drugs or alcohol have been used, it can affect how long it takes the Hysingla to leave the system.
Different drug tests can be used to determine if someone has used an opioid medication like Hyslinga ER. So how long does Hysingla ER stay in your urine, hair and blood? In a urine screening, which is the most commonly done type of drug test, hydrocodone may be detectable for four days or more. This can be longer, depending on some of the factors named above, such as dosage and how long someone’s been using hydrocodone. In a hair test, drugs like Hyslinga ER can show up for up to 90 days after the last use. Blood tests tend to have the shortest detection window. A blood test might be able to detect the use of hydrocodone for up to 24 hours after it’s used.
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