How Long Does Emsam Stay in Your System?
- 1. How Long Does Emsam (Selegiline) Stay In Your System?
- 2. Emsam (Selegiline) Prescription Facts
- 3. Emsam (Selegiline) Regulations
- 4. Most Commonly Abused Drugs Containing Emsam (Selegiline)
- 5. How Emsam (Selegiline) Affects the Brain and Body
- 6. Half-Life of Emsam (Selegiline)
- 7. Factors That Influence How Long Emsam (Selegiline) Stays in Your System
- 8. How Long Does Emsam (Selegiline) Stay in Your Urine, Hair, and Blood?
When Emsam is prescribed to treat depression, it’s issued in the form of a transdermal patch. Oral Emsam, taken in pill form, is prescribed to patients with Parkinson’s disease to mitigate the severity of symptoms by boosting dopamine production.
Selegiline is prescribed to patients with depression after they do not respond well to other medications like selective serotonin reuptake inhibitors (SSRIs) and tricyclics. SSRIs and tricyclics have a higher rate of effectiveness and come with fewer complications than MAO inhibitors such as Emsam.

Other antidepressants and medications that boost levels of serotonin in the brain should not be taken while being treated with Emsam. Combining selegiline with SSRIs or tricyclics can lead to serotonin overload and psychosis.
Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help.
Your call is confidential, and there's no pressure to commit to treatment until you're ready. As a voluntary facility, we're here to help you heal -- on your terms. Our sole focus is getting you back to the healthy, sober life you deserve, and we are ready and waiting to answer your questions or concerns 24/7.
Speak to an Intake Coordinator now.352.771.2700
Methylenedioxymethamphetamine (MDMA) is the main component in pressed ecstasy pills that induces the drug’s characteristic euphoria by boosting serotonin. Combing MDMA with Emsam is a potentially hazardous combination that can result in serotonin syndrome, a dangerous condition with the potential to cause psychosis and permanent brain damage.
At high doses, however, selegiline will begin impacting all MAO pathways and affect a wider variety of neurotransmitters. At low-to-moderate doses, Ensam’s effects are focused on increasing the expression of the neurotransmitters dopamine and norepinephrine. Dopamine’s primary function is to increase focus and motivation. Norepinephrine plays a similar role in the brain and contributes to a variety of functions from digestion to mental health.
Oral Emsam is primarily metabolized in the liver and gut wall. Its metabolites bind to plasma proteins at a rate of 94%. Transdermal selegiline results in significantly higher absorption of the drug and significantly higher exposure to metabolites that would be excreted through the feces and urine.
If you or a loved one is struggling with substance use disorder, don’t delay. Go online to www.TheRecoveryVillage.com or call 24/7 to our toll-free hotline at 855-548-9825 to learn more about the road to recovery. We can help you overcome your addiction today.
Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.
Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help.
Your call is confidential, and there's no pressure to commit to treatment until you're ready. As a voluntary facility, we're here to help you heal -- on your terms. Our sole focus is getting you back to the healthy, sober life you deserve, and we are ready and waiting to answer your questions or concerns 24/7.
Speak to an Intake Coordinator now.352.771.2700