Mixing Xtampza ER and Alcohol
Xtampza ER should never be mixed with alcohol because both substances depress the activity of the central nervous system. The combined use of these drugs can lead to liver complications and potentially life-threatening respiratory depression.
Xtampza ER should not be mixed with other central nervous system depressants, including other opioids, muscle relaxants, tranquilizers, and non-benzodiazepine sedative hypnotics. MAO inhibitors that are indicated to treat depression should also not be taken concurrently with Xtampza ER.
Concomitant use of Xtampza ER with certain antibiotics, antifungals, and protease inhibitors may increase plasma concentrations of Xtampza ER and lead to the increased risk of adverse reactions, including potentially fatal respiratory depression. Discontinuing use of rifampin, phenytoin, carbamazepine, and other similar medications while taking Xtampza ER can result in similar complications.
Extreme caution should be exercised when first administering Xtampza ER. The first 24 to 72 hours is the riskiest time. Patients should be closely monitored for the development of severe respiratory depression and allergic reactions.
The liver is the primary processing center for both alcohol and Xtampza ER. The combination of these substances can lead to dangerously elevated blood plasma concentrations of alcohol and Xtampza ER. This is the result of inefficient metabolism and extended clearance times due to an overtaxed liver. Patients with poor liver health have a higher likelihood of experiencing such complications.
Other factors that can affect the chance of opioid or alcohol toxicity include the patient’s age, weight, overall physical health, kidney function, opioid tolerance, and genetic predispositions. Certain individuals are naturally more tolerant of higher doses of Xtampza, even when combined with alcohol. The combined use of Xtampza ER and alcohol can increase the severity of adverse reactions from each substance. Blackouts, nausea, vomiting, poor coordination, pinpoint pupils, muscle flaccidity, fainting, confusion, loss of consciousness, coma, and death are associated risk factors of the concomitant use of alcohol and Xtampza ER.
Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options, and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or another qualified healthcare provider.
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