Sublimaze Mixing It and Alcohol

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Sublimaze should never be mixed with alcohol. Concomitant use of Sublimaze or other fentanyl drugs with alcohol increases the risk for severe respiratory depression and overdose. Sublimaze distribution and administration are closely regulated by the Federal Drug Administration (FDA). Sublimaze is classified as a Schedule II substance and it has a high potential for addiction and fatal overdose.

Use of other central nervous system depressants with Sublimaze may decrease pulmonary arterial pressure and lead to hypertension. Extra care should be taken when administering Sublimaze to elderly or debilitated patients due to the increased risk of complications. The minimum effective initial dose should always be used. Doses can then be titrated gradually until the desired effect is achieved.

Nitrous oxide can produce cardiovascular depression when administered with high doses of Sublimaze. When tranquilizers are used with Sublimaze, pulmonary arterial pressure can decrease and lead to clinically significant hypotension (low blood pressure). In the postoperative setting, patients should be closely monitored for orthostatic hypotension (low blood pressure upon standing). Elevated blood pressure has been reported in the use of Sublimaze with neuroleptics. In these cases, postoperative monitoring of EEG patterns is necessary until patterns return to normal.

Sublimaze Mixing It and Alcohol
Sublimaze is a brand name fentanyl citrate injection. It’s indicated for the management of pain associated with surgery. Sublimaze may be administered during premedication, anesthetic periods, induction, maintenance, and postoperatively in the recovery room.

Sublimaze has a rapid onset and short duration of action. It can be given via intravenous or intramuscular injection. When administered intravenously, Sublimaze can take effect almost immediately and provides pain relief for 30 to 60 minutes. When administered via intramuscular injection, Sublimaze can take up to eight minutes to take effect and has an active duration of up to two hours.

The most common side effects of Sublimaze include apnea, bradycardia (slow heart rate), muscle rigidity, and respiratory depression. Skeletal muscle rigidity can be managed with a neuromuscular blocking agent. Severe cardiovascular depression may also occur and should be closely monitored during dosage initiation and titration.

Serotonin syndrome is a potentially life-threatening condition that can occur in patients taking serotonergic medications such as selective serotonin reuptake inhibitors (SSRIs) for depression. Adrenal insufficiency is another potential complication. Adrenal insufficiency occurs when the adrenal gland can no longer keep up with the body’s demands for the stress hormone cortisol. Adrenal insufficiency can be treated with corticosteroid replacement therapy.

Sublimaze should not be mixed with alcohol or other central nervous system depressants. The combined use of Sublimaze with alcohol may cause severe hypotension that can lead to more severe cardiovascular complications. Concomitant use of alcohol and Sublimaze may cause profound respiratory depression, sedation, coma, and even death. Benzodiazepines and other sedative/hypnotics should also be avoided.
Sublimaze has a high risk of overdose and a long list of severe interactions with various medications. As a rule, any substance that acts directly to suppress the activity of the central nervous system should be avoided without dedicated medical supervision. Deterioration in the patient’s respiratory drive can be sudden and catastrophic.

If you or someone you know needs help recovering from an opioid misuse disorder, The Recovery Village is available to answer any questions you may have. Visit us online at or call our toll-free 24/7 hotline at 855-548-9825. We can help you overcome your addiction today.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.