What Is Serzone (Nefazodone)?

Serzone, also known by its generic name nefazodone, is a synthetic antidepressant. Serzone can also be used to treat aggressive behavior and panic disorders. For nefazodone to be effective, it needs to be taken regularly at the same time every day.

Some common side effects of Serzone include dizziness, drowsiness, lightheadedness, nausea, dry mouth and constipation. If any of these effects last a long time or get worse, call your doctor.

How Long Does Serzone (Nefazodone) Stay In Your System?

Although Serzone is removed from the body quicker than most other antidepressants, certain factors still come into play when estimating how long it will stay in your system such as age, metabolism, usage frequency, organ functions and more.

Serzone (Nefazodone) Prescription Facts

According to the U.S. Center for Disease Control, the use of antidepressants is on the rise. Here are some statistics on antidepressant use in the United States:

  • Between 2011 and 2014, nearly 13 percent of all U.S. residents took an antidepressant within the last month.
  • Females are twice as likely to take antidepressants than males.
  • Non-Hispanic white Americans are the most likely to take antidepressants than any other race.

Serzone (Nefazodone) Regulations

Serzone should only be taken if your doctor prescribes it to you. Do not take nefazodone recreationally.

Most Commonly Abused Drugs Containing Serzone (Nefazodone)

The most commonly misused drugs, which contain the medication Serzone, are Serzone itself and its generic form, nefazodone.

How Serzone (Nefazodone) Affects The Brain And Body

Serzone works because of its effect on the brain’s natural compounds called neurotransmitters. Nefazodone is described as a serotonin antagonist and reuptake inhibitor (SARI) because it is a potent serotonin reception and weak serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

Half-Life Of Serzone (Nefazodone)

Serzone has a short half-life of two to four hours.

Factors That Influence How Long Serzone (Nefazodone) Stays In Your System

Your Serzone treatment must be stopped for your body to remove the medication from its system. Talk to your doctor about creating a tailored plan to gradually lower your nefazodone dosage over time.

Each patient responds to medications differently, and Serzone is no different. As we mentioned before, several factors influence how long nefazodone stays in your system. These factors are:

  • Age: How old you are influences how long Serzone stays in your system because younger people typically have more efficient body functions than older people. The more efficient the body functions are, the quicker Nefazodone is removed.
  • Body height/weight/fat: The amount of Nefazodone you are prescribed is partially due to your height, weight and body fat. If you are a bigger person, your dose will be higher than a smaller person. The higher the dose, the longer Serzone stays in your system.
  • Genetics: Genes are another important factor in how long nefazodone stays in your body because genetics affect your metabolism functions. If your metabolism is fast, Serzone will be eliminated quickly.
  • Kidney and liver functions: The kidneys and liver eliminate all medications you put in your body. If these organs are damaged in any way, Serzone may linger in your system for longer.
  • Usage frequency: If your Serzone treatment lasted several years, it would take longer for your body to rid itself of the medication than someone who had only taken it for a few months.

How Long Does Serzone (Nefazodone) Stay In Your Urine, Hair and Blood?

Depending on the type of drug test you take, nefazodone may show up in your results. This is because certain tests have longer windows of detection than others. The following is an estimate of just how long nefazodone will stay in your system after undergoing different tests:

  • Urine: Serzone can usually be found in your urine within a few hours of taking it. Typically, 55 percent of nefazodone is excreted in the urine.
  • Hair: Drug tests involving hair follicles have the longest detection window. Serzone can be detected in your hair for a maximum of 90 days after you last used it.
  • Blood: Nefazodone can usually be detected in your blood a few hours after using it. Because of Serzone’s short half-life, it usually is not detected in your blood after a few days.

If you or someone you know is struggling with substance use disorder, help is available. Contact The Recovery Village today to receive information on how you can embark on a life-long recovery.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.