Oxymorphone Hydrochloride Overdose
- 1. Oxymorphone Hydrochloride Overdose Amount, Signs & Treatment
- 2. Symptoms of Oxymorphone Hydrochloride Overdose
- 3. Oxymorphone Hydrochloride Overdose Signs
- 4. How Much Oxymorphone Hydrochloride Leads to Overdose?
- 5. Oxymorphone Hydrochloride Dependency
- 6. Oxymorphone Hydrochloride Overdose Treatment
- 7. Oxymorphone Hydrochloride Overdose Statistics
Oxymorphone hydrochloride is only available in the US as an extended-release tablet. Tablets are available in 5 mg to 10 mg tablets. Initial doses should never exceed 20 mg. Additional doses may be administered as needed every four to six hours.
In addition to insufficient breathing, unresponsiveness, and pinpoint pupils, the person may exhibit any of the following warning signs: dizziness, blue lips, nails, or skin, drowsiness, irregular heart rate, clammy/cold skin, fluctuating blood pressure, chest pain or discomfort, numbness in the extremities, and loss of consciousness. As a rule, if you cannot confirm that the patient is aware of their surroundings or if they are lethargic and uncoordinated, they should be considered at risk of an overdose.
The effects of the drug last for anywhere from four to six hours, at which time the patient may be given another dose as needed. Patients should be monitored closely for respiratory depression during the first 24-72 hours following the initiating therapy. For subcutaneous, intramuscular injections of the drug, the initial dosage should not exceed 1 mg every four to six hours. No more than 0.5 mg of oxymorphone hydrochloride should be administered intravenously at any one time.
Oral oxymorphone hydrochloride is best taken on an empty stomach at least one hour before eating in order to ensure maximum absorption. Due to the high potential for developing dependence and the risk of overdose, clinicians are advised to underestimate a patient’s 24-hour dose. If, after 24 hours, the patient’s dosage appears to be insufficient, doses should be increased with caution until symptoms of pain subside.
Oxymorphone does more than simply reduce the experience of pain. It also elevates levels of neurotransmitters in the brain that are responsible for feelings of pleasure. One of the primary neurotransmitters that oxymorphone hydrochloride acts on is dopamine. The neural pathways that trigger dopamine production may begin to atrophy as the patient becomes dependent upon the drug.
When the individual stops taking the drug, the lack of dopamine production can lead to an inability to experience pleasure. In response, the patient may begin taking larger doses of oxymorphone hydrochloride in search of an enjoyable high. This is when the patient becomes at serious risk for severe respiratory depression and overdose.
The treatment priority is, first and foremost, administering an opioid antagonist like naloxone. Naloxone is available as an injection and nasal spray. Naloxone forces oxymorphone hydrochloride to release itself from the opioid receptor sites, which negates the effects of the drug. In many patients, naloxone triggers the immediate onset of withdrawal symptoms. If administration of an opioid antagonist like naloxone is delayed, life-saving procedures may be needed to secure the patient’s airway and provide adequate oxygenation.
For more information on the risks associated with oxymorphone hydrochloride use, visit www.TheRecoveryVillage.com. Our toll-free hotline is open 24/7. Contact us any time at 855-548-9825.
Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.
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