Opana (oxymorphone) is an addictive substance. The detox process for Opana can take days, weeks or even months. Success is most likely with medical assistance.

Article at a Glance:

  • Opana withdrawal symptoms can include watery eyes and nose, agitation, nausea, vomiting and diarrhea.
  • Symptoms start within 12 hours after the last dose and can continue for five days.
  • Quitting Opana “cold turkey” may worsen withdrawal symptoms and put you at risk of relapse.

What Is Opana (Oxymorphone) Withdrawal?

Withdrawal occurs as a part of the detox process, which is the body’s elimination of substances. If a person is suffering from Opana addiction, their body has become dependent on the drug. Because their body relies on the drug to function, someone can feel ill if they go without the substance. This ill feeling is withdrawal, characterized by physical and psychological symptoms that accompany the body adjusting to a lack of the drug.

The brand name drug Opana has been discontinued, so any pills labeled Opana are likely expired or illegally made. However, generic, extended-release versions of oxymorphone are still available by prescription in the U.S.

Opana (Oxymorphone) Withdrawal Symptoms

Some symptoms of Opana withdrawal can include:

  • Sweating
  • Tears
  • Chills
  • Big pupils
  • Watery eyes
  • Restlessness
  • Yawning
  • Irritability
  • Nausea
  • Vomiting
  • Diarrhea
  • Joint pain
  • Insomnia

How Long Does Opana (Oxymorphone) Withdrawal Last?

The acute phase of Opana withdrawal usually lasts up to five days. Initial symptoms can feel like a mild case of the flu and may also include anxiety, insomnia, agitation and drug cravings. During the peak of withdrawal, a person may feel sick, have chills and experience cravings. Symptoms usually start going away after a week, but symptoms can last longer in some cases. This is known as post-acute withdrawal syndrome (PAWS). Someone with PAWS can experience depression or anxiety for weeks or months after their last dose.

Opana Withdrawal Timeline

The oxymorphone withdrawal timeline describes how long a person can feel symptoms after they stop using the drug. This timeline depends on many factors, like how long and how often the drug was used, how quickly the drug was stopped, and whether or not other substances were involved. However, the Opana withdrawal timeline generally follows the same schedule:

  • Within 24 hours: Withdrawal symptoms can start within 12 hours after the last dose of Opana.
  • Within 48 hours: Withdrawal symptoms peak after 24 to 48 hours after the last Opana dose.
  • Within one week: Symptoms improve after the first 48 hours, then resolve over the next three to five days.
  • Within the next few months: PAWS can lead to mental changes, depression, anxiety and cravings for weeks or months after quitting Opana.

Managing Symptoms of Oxymorphone Withdrawal

The detox process, including managing withdrawal symptoms, is best completed under the supervision of a medical professional. For example, doctors may reduce the dose of the drug slowly. This action is called tapering. Tapering drug use can help someone avoid uncomfortable and dangerous withdrawal symptoms.

Medical detox can also be used as the first step of addiction treatment. This is especially important for those with co-occurring mental health problems and those who use multiple substances. People should avoid trying to detox at home without proper help. While oxymorphone withdrawal can be dangerous and cause extreme discomfort, which could present a heightened risk of relapse.

Oxymorphone Medications And Detox

Since oxymorphone is an opioid, people can take maintenance drugs to reduce withdrawal symptoms and drug cravings. This usage method makes it more likely that people can complete drug treatment.

While medication-assisted treatment (MAT) using methadone or buprenorphine is the gold standard of opioid withdrawal treatments, other therapies are available.

Naltrexone is one such option. It doesn’t replace the effects of opioids, but it does deter people from using more opioids by blocking their intended effects. This drug can also limit cravings. Speak to a doctor to learn about other medications that can help people with an opioid use disorder.

Continue reading at Medication-Assisted Treatment →

Why Choose a Medical Detox Center

Choosing to detox under medical supervision at a medical detox center can help you overcome addiction while getting the care you need. Withdrawal symptoms and mental health symptoms can be quickly treated and managed. In addition, MAT with methadone or buprenorphine may be used.

After detox, you may begin addiction rehab. At The Recovery Village, a detox center is part of a larger treatment center and is considered the first step of recovery. A continuum of care is available, from inpatient to outpatient care and on toward your sober future.

If you or someone you love struggles with Opana, or if you have questions about detox or other treatment options, call The Recovery Village to discover what can work for you.

Can I get off Opana cold turkey?

Stopping Opana cold turkey without medical help is not recommended. This can lead to severe withdrawal symptoms that make it difficult to avoid relapse.

Can I get off Opana without rehab?

Staying off Opana long-term without rehab is unlikely. Undergoing a rehab program that is at least 90 days in length is the best way to stay off Opana long-term.

Visit the following websites to learn about The Recovery Village’s network of drug and alcohol rehabilitation facilities. Call today for admissions. Each center is ready to help people learn how to cope with their addiction and uncover the root causes for their substance use disorder.

  • Orlando Recovery Center: A premier rehabilitation facility in Orlando, Florida that helps individuals recover from addiction and substance use disorders. The center also offers the opportunity to treat co-occurring disorders.
  • The Recovery Village Columbus: Located in Ohio, this facility provides inpatient, outpatient and aftercare treatment for people looking to begin detox. The center provides individualized plans to help patients through recovery while addressing their unique co-occurring disorders or any setbacks that may happen during recovery.
  • The Recovery Village Palmer Lake: In Colorado, this facility offers inpatient, outpatient and intensive outpatient treatment for individuals looking to kick-start their journey to recovery.
  • The Recovery Village Ridgefield: Located right in southern Washington, this facility provides patients with outpatient and aftercare programs. Just 20 minutes outside of Portland, this facility assists individuals who are ready to begin treatment.
  • The Recovery Village: In Umatilla, Florida, this is a rehabilitation facility that provides resources for individuals seeking drug and alcohol treatment. There are inpatient, outpatient, intensive outpatient and partial hospitalization treatment programs available for those suffering from Ambien addiction.
  • IAFF Center of Excellence: Specializes in assisting firefighters who struggle with behavioral health problems and addiction. Members can enter the recovery process sooner so they can return back to work as quickly as possible. Inpatient, partial hospitalization and intensive outpatient programs are all available at this facility, where patients can address their Ambien addiction in a safe, supportive environment.
  • Denver Mental Health & Counseling: Denver Mental Health and Counseling by The Recovery Village is a physician-led outpatient center specializing in evidence-based addiction and mental health treatments, offering services such as TMS, IOP, and personalized care for both ongoing and new patients, dedicated to fostering long-term recovery and overall well-being.
  • The Recovery Village Palm Beach at Baptist Health: The Recovery Village Palm Beach at Baptist Health is a premier physician-led treatment center in South Florida, offering a comprehensive spectrum of services from medical detox to outpatient programs for alcohol, drug, and co-occurring mental health conditions, with a commitment to rejuvenating lives, families, and communities, and facilitating same-day admissions.
  • The Recovery Village Atlanta: Located in Roswell just outside downtown Atlanta, is a 62-bed physician-led treatment facility offering a comprehensive range of services, from medical detox to outpatient care, specializing in alcohol, drug, and co-occurring mental health conditions, dedicated to transforming lives, families, and communities throughout Georgia.
  • The Recovery Village Kansas City: The Recovery Village Kansas City, an 80-bed facility in Raytown just 10 miles from downtown, offers a comprehensive range of evidence-based treatments for addiction and mental health conditions, overseen by physician leaders, and is dedicated to revitalizing lives, families, and communities throughout the Midwest.
  • The Recovery Village Cherry Hill at Cooper Health: The Recovery Village Cherry Hill at Cooper, situated just 20 minutes from Philadelphia, is a leading rehab facility in South Jersey providing comprehensive, evidence-based addiction and mental health treatments, ranging from medical detox to teletherapy, with a dedicated team committed to guiding adults on their path to lifelong recovery.

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Editor – Erica Weiman
Erica Weiman graduated from Pace University in 2014 with a master's in Publishing and has been writing and editing ever since. Read more
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Medically Reviewed By – Dr. Jessica Pyhtila, PharmD
Dr. Jessica Pyhtila is a Clinical Pharmacy Specialist based in Baltimore, Maryland with practice sites in inpatient palliative care and outpatient primary care at the Department of Veteran Affairs. Read more

National Institute on Drug Abuse. “Principles of Drug Addiction Treatment: A Research-Based Guide (Third Edition).” January 2018. Accessed December 12, 2021.

Substance Abuse and Mental Health Services Administration. “Protracted Withdrawal.” July 2010. Accessed December 12, 2021.

American Society of Addiction Medicine. “The National Practice Guideline for the […]2020 Focused Update.” December 18, 2019. Accessed December 12, 2021.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.