How Long Does Oxycodone Stay in Your System?

Quick Overview

Oxycodone’s half-life, or the time that it takes for half of the drug to exit your body, can range from 3 ½ to 5 ½ hours. It can take up to 20 hours before the drug is completely out of your system.

However, there are several factors that can affect how long the drug remains in your body, such as height, weight, and food consumption.

  • Oxycodone can be detected in your saliva within 15 to 30 minutes of dosage and can be detected for up to 1 to 4 days.
  • In your blood, oxycodone within 15 to 30 minutes of dosage and can be detected for about 1 day.
  • Oxycodone can be detected in your urine within 2 hours of dosage and can be detected for up to 3 to 4 days.
  • In your hair, oxycodone can be detected 5 to 7 days after dosage and can be detected for up to 90 days.

Oxcodone pills sitting on a table.
Oxycodone and also hydrocodone are prescription medicines that are intended to treat short-term pain, often caused by either surgery or a serious injury. They can also, in some cases, be used to treat chronic or long-term pain resulting from injuries as well as illnesses and conditions like cancer or arthritis. These medicines can be taken alone, or they can be paired with something else, such as acetaminophen, and Oxycodone is a powerful narcotic.
Oxycodone works by interrupting central nervous system pain signals. When you take this medicine, your body becomes unable to send pain signals to your brain.

Primarily used to treat pain that’s moderate to severe, patients on oxycodone usually take it all the time for a set period of time until their care provider tells them to stop. Oxycodone, as well as hydrocodone, have a high risk of addiction and dependency, which is why it’s important for people to take them only as they’re instructed.

Oxycodone is a Schedule II drug, which means it carries a high risk for abuse potential. Oxycodone in its pure form is available as the brand name Oxycontin, which is a tablet.

Some of the side effects of using oxycodone can include nausea, vomiting, dizziness, dry mouth, itching, and in a severe case, rapid heart beat, confusion, and painful urination.

Oxycodone, as well as Percocet, which is the combination of oxycodone and acetaminophen, usually has a half-life of anywhere from 3 ½ hours to 5 ½ hours. This means that for the average person who takes oxycodone it will take nearly 20 hours for oxycodone to be completely cleared out of the system.

In addition to the drug itself being present, there may be metabolites present in your system that would affect how long it takes for it to clear, so those substances might be detectable for up to two days.

The exact amount of time it would take for oxycodone to leave your system depends on quite a few individual variables. For example, if you’re well-hydrated and have just eaten before you take a dose of oxy, there can be an impact on absorption of the drug, as well as metabolism and how quickly you excrete it. For example, if you were to take a tablet on a full stomach, it could alter how it’s absorbed.

Liver enzymes also metabolize oxycodone, so if you have taken the drug and you have problems with kidney or liver function, it may take your body longer to excrete the drug.

Also relevant to determining how long oxycodone stays in your system include:

  • There are certain enzymes in the liver and people with higher stores of certain enzymes may be able to eliminate oxycodone from their system more It’s usually younger people that have higher levels of the particular enzyme that impact the elimination of oxycodone.
  • Age is important when looking at how long oxycodone and other drugs stay in the system. Older people generally aren’t able to excrete drugs as quickly as younger people, largely because of reduced kidney and liver function, as well as the potential for other health problems that can slow down metabolism.
  • Body weight and fat, as well as height, can play a role. The higher the dose a person takes of Oxycodone as compared to their height and weight, the longer they retain Also, the more body fat you have, the faster you’re likely to excrete it.
  • Your personal basal metabolic rate can determine how quickly you metabolize and ultimately excrete oxycodone and other drugs. The higher your metabolic rate, the more quickly your body can break down and get rid of substances including oxycodone.
  • Most of the oxycodone is eliminated from the body through urine, so your individual urinary pH can be important in the excretion process. The more alkaline your urine, the slower it will take oxycodone to be eliminated.
  • If you’re someone who takes oxycodone frequently, it may take your body longer to clear it from your system. If you’re someone who takes it regularly or you’ve taken it for a long period of time, you start to accumulate it in areas of your body, which makes it more difficult for it to be completely out of your system.
There are several key reasons many people might wonder how long it takes oxycodone to leave their system. Reasons might include detox or for drug testing, but people may also wonder because of the high risk of an overdose that can come with drugs like oxycodone. If you take more of the drug after the therapeutic effects of your last dose wear off, but the drug hasn’t left your system, you’re increasing the likelihood of an overdose.
Different types of tests will have different testing windows at which substances can be detected. With a saliva test, oxycodone usage usually shows up within 15 to 30 minutes of taking a dose, and it’s detectable anywhere from 1-4 days.

In a blood test, it will show up in about 15 to 30 minutes as well and will stop being visible in a test within about a day.

With urine, oxycodone can show up anywhere from 0-2 hours after taking a dose, and it can be seen for anywhere from 3-4 days on average.

A hair test can take the longest for the drug to actually show up after it’s taken, being anywhere from 5-7 days later, but it also has the longest testing window by a lot, at more than 90 days.

Oxycodone: How Long Does Oxycodone Stay In Your System?
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Oxycodone: How Long Does Oxycodone Stay In Your System? was last modified: July 18th, 2017 by The Recovery Village