Ondansetron for Opiate Withdrawal
What Is Ondansetron?
Ondansetron is a generic drug available under the brand name Zofran. Ondansetron is available in the form of a disintegrating tablet, solution, film and an IV variation. The tablet is most commonly administered to patients to prevent nausea and vomiting. For the most part, ondansetron is used for nausea and vomiting relating to medical treatments including chemotherapy, radiation, and surgery. It’s classified as an antiemetic. Antiemetics are a class of drugs that reduce nausea and vomiting. Ondansetron is believed to work by blocking serotonin release in the central nervous system and the stomach, preventing serotonin from causing nausea and vomiting.
There are side effects of ondansetron including drowsiness, headache, and diarrhea. This medication may also cause constipation and dizziness. One of the most serious side effects of ondansetron is serotonin syndrome, although this is rare. People are advised against combining ondansetron with other medications affecting serotonin levels for this reason. There is some evidence ondansetron for opiate withdrawal could be useful, but why is that?
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