Onsolis How Long Does It Stay in Your System?

Onsolis Addiction Hotline

24/7, Toll-Free, Confidential


Onsolis is a transmucosal form of pain medication containing fentanyl citrate. Onsolis is a patch you put on the inside of your cheek in order to allow the medication to be released through your buccal mucosa, and throughout your body. Different strengths are obtained through multiple patches placed in the mouth; however, there is a limit to no more than 1200 mcg. Onsolis will dissolve within 15 to 30 minutes of application, and you shouldn’t eat or drink until it’s dissolved. Another dose of Onsolis can be given no less than 2 hours after that dose.

There are some factors, detailed below, which will determine how long Onsolis will stay in your system, but the average is about 77 hours.

Inform your doctor if you are experiencing any side effects from Onsolis and avoid using any interaction medications, including alcohol, while the drug remains in your system. If you’re unsure about the safety of taking other medications or drinking alcohol after placing your Onsolis film, talk to your doctor as some interactions can be fatal.

Onsolis How Long Does It Stay in Your System?
Onsolis is an opioid painkiller, which is used for sudden breakthrough pain for patients who are already on a regular opioid regimen. The medication is delivered directly to the inside of the cheek, using water-soluble polymeric films. Patients not already on a chronic opioid therapy schedule are not recommended to apply Onsolis. Using Onsolis without already taking opioids on a regular basis can lead to life-threatening respiratory depression and death.

Onsolis is not like other prescriptions containing fentanyl citrate. Its dosage cannot be changed to resemble other prescriptions because it’s absorbed differently. Treating it the same as other products containing fentanyl could lead to an accidental overdose. Only apply Onsolis as directed by your doctor.

Onsolis can only be prescribed to patients who agree to participate in the TIRF REMS Access program. The TIRF REMS Access program is designed to lessen the misuse, abuse, addiction, overdose and serious complications due to medication errors.

As with most prescriptions, there is a chance of side effects while using Onsolis. These side effects can include:

  1. Respiratory depression
  2. Circulatory depression
  3. Hypotension
  4. Shock
  5. Nausea
  6. Dizziness
  7. Vomiting
  8. Constipation
  9. Diarrhea
  10. Dry mouth
  11. Abdominal pain
  12. Dehydration
  13. Loss of appetite
  14. Anxiety
  15. Extreme sleepiness

If you experience any side effects, contact your doctor right away as some may be serious. Your doctor can help you decide if Onsolis is the right choice to handle your breakthrough pain.

Onsolis contains fentanyl citrate, which is listed under the Controlled Substance Act in the United States as a Schedule II controlled substance. Schedule II controlled substances have a high potential for addiction and abuse. Refills of prescription drugs on this list are not allowed and only a doctor who is licensed to prescribe opiates can prescribe Onsolis.
Onsolis How Long Does It Stay in Your System?
Onsolis is not present in any other drugs, as it’s a delivery system containing fentanyl citrate. Fentanyl, and thereby Onsolis, has a high potential for addiction, so it’s important to only use Onsolis if it’s prescribed by your doctor.

Onsolis affects receptors in the central nervous system that regulate how you perceive pain. This prescription also affects the respiratory, gastrointestinal and immune systems.

Inform your doctor about all medications you are taking, including prescription, non-prescription, and supplements, in order to make sure you have no adverse reactions when Onsolis is applied.

Do not abruptly stop using Onsolis, as there may be severe withdrawal symptoms. Consult your doctor and have them assist you in weaning off of this prescription.

The half-life of a medication is the time that it takes for the effectiveness to be cut in half after a person stops taking the last dose. The terminal half-life for Onsolis is about 14 hours.

There are several factors that influence how long fentanyl will stay in your system. These factors include age, weight, body fat, metabolism, liver and kidney function, dosage, length of time taking the medication, medical condition, and other medications you are taking.

Since there are so many factors influencing the length of time fentanyl is in your system, consult your doctor before taking any other medications or drinking alcohol after you’ve stopped applying Onsolis.

Onsolis is an opioid and will show up in a drug test screening, so it’s important to inform your drug test administrator that you are taking or have recently taken this prescription. Onsolis will stay in your urine and blood for at least 3 days, but will stay in your hair for considerably longer. Drug test of your hair can show traces of Onsolis and other medications for up to 90 days after your last application.

If you feel that you or a loved one is misusing or abusing Onsolis, don’t wait to get help. Go online to www.TheRecoveryVillage.com or call our 24/7 toll-free hotline at 855-548-9825 to learn more about the road to recovery. We can help you begin to overcome your addiction today.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.