Treatment for Psychosis

Psychosis has a reputation for being untreatable or difficult to treat. It is actually responsive to a wide range of treatment modalities, many of which yield immediate effects. Early intervention can be particularly effective. Twenty-five percent of people who experience an episode of psychosis never have another episode after they receive treatment for psychosis.

Of the people for whom a psychotic disorder becomes a chronic condition, many have long periods in which they are symptom-free. With the right psychosis treatment and supports in place, they are able to respond quickly and intervene when symptoms recur, allowing them to manage their illnesses and live normal lives.

Medications for Treating Psychosis

Due to the significant and well-documented influence of brain chemistry on psychotic disorders, the first step in treatment is usually starting a psychosis medication regimen. The right medication for psychosis can disrupt or change processes in the brain that cause or intensify psychotic symptoms. After starting medication, many people experience a complete remission of positive symptoms of psychosis, like hallucinations and delusions.

Antipsychotic Medications

The most common medications for psychosis are antipsychotic medications. Nearly all of them work by blocking dopamine, which research shows is overactive in the brains of people with psychotic disorders.

First-generation antipsychotics were developed in the 1950s and effectively treat psychotic symptoms. However, they are now less commonly used due to serious side effects associated with them, such as tardive dyskinesia and other motor problems.

First-generation antipsychotic medications are also sometimes called “typical antipsychotics.” They include the following:

  • Fluphenazine (Prolixin)
  • Haloperidol (Haldol)
  • Chlorpromazine (Thorazine)

Second-generation, or atypical, antipsychotics were developed in the 1980s. This medication for psychosis is just as effective as first-generation antipsychotics but with fewer side effects. Many atypical antipsychotics are associated with weight gain and increased risk of developing Type 2 diabetes, which is serious but less life-altering than are side effects of older antipsychotic drugs. An up-to-date psychosis medication list will typically feature the following drugs:

  • Clozapine (Clozaril)
  • Aripiprazole (Abilify)
  • Risperidone (Risperdal)
  • Quetiapine (Seroquel)
  • Olanzapine (Zyprexa)
  • Ziprasidone (Geodon)

Antipsychotic drugs can have an impact within hours, and they can alleviate agitation and confusion within minutes. However, psychosis medications usually take several weeks to become fully effective.

As antipsychotic drugs reach therapeutic levels, they start clearing the most severe symptoms of psychosis. While some people with severe psychotic disorders never experience total relief from these symptoms, many remain completely free of delusions or hallucinations as long as they continue taking these medications.

Antidepressant Medications

Antidepressant medications are often used to augment antipsychotic medications in the treatment of psychotic disorders. They are commonly used to treat resistant symptoms in schizophrenia, especially negative and mood symptoms like flat affect and anhedonia.

A 2015 study suggested that at least 25 percent of people with schizophrenia experience comorbid depression. Research shows that antidepressants not only alleviate depressive symptoms but effectively reduce negative symptoms of schizophrenia when combined with antipsychotic medications. Antidepressants shown to be effective when used in combination with antipsychotics include:

  • Mirtazapine (Remeron)
  • Citalopram (Celexa)
  • Fluoxetine (Prozac)
  • Sertraline (Zoloft)

The antidepressant medications used as part of a medication regimen depends on a range of factors, like comorbid illnesses and interactions with other medications.

Anti-Anxiety Medications

Anxiety disorders affect over 18 percent of people in the United States each year. They are even more prevalent for people with psychotic disorders. One analysis showed that nearly 40 percent of people with schizophrenia had at least one comorbid anxiety disorder. Some antidepressants are also used to effectively treat anxiety disorders.

These include:

  • Citalopram (Celexa)
  • Paroxetine (Paxil)
  • Sertraline (Zoloft)
  • Venlafaxine (Effexor)

Benzodiazepines like lorazepam (Ativan) are sometimes used for people with schizophrenia and other psychotic disorders to treat symptoms of anxiety and psychotic agitation.

Therapy for Psychosis

While medications are central to the treatment of psychotic disorders, therapy can also be essential. Different therapeutic styles focus on different treatment goals and areas of concern, but many types of therapy for psychosis can help people manage their illness and maintain a higher quality of life.


Psychotherapy is the general term for any form of talk therapy in which a person talks to a clinician who helps them process emotional material and work toward personal goals.

Traditional forms of psychotherapy were insight-based and not considered to be helpful for people with even temporary cognitive deficits or distorted thought processes. Psychotherapy has since developed a strong supportive component that makes it more broadly applicable. Supportive psychotherapy focuses on the formation of a good relationship between a therapist and client, which can help people with psychotic disorders by reducing paranoia, promoting acceptance of treatment, and encouraging adherence to medication and treatment plans.

Cognitive Behavioral Therapy

Cognitive behavioral therapy (CBT) is especially effective for people with psychotic disorders. Disorganized and irrational thought processes are common in these conditions and CBT targets these symptoms.

By helping clients monitor and analyze their thought processes more closely than they otherwise would, cognitive behavioral therapy for psychosis helps people with these disorders make rational connections and recognize when psychotic symptoms are arising. It also helps strengthen reality testing skills when a person’s illness makes it harder for them to discern internal from external events.

Cognitive Enhancement Therapy

Cognitive enhancement therapy (CET) was developed for people with schizophrenia and focuses even more intensely on cognitive processes, especially social cognition than CBT does. It involves a suite of connected interventions, including neurocognitive enhancement exercises done on computers, structured groups with homework assignments and individual coaching.

Research shows that this intervention yields significant positive outcomes, including improved emotional information processing, cognitive organization and functional outcomes like higher rates of employment.

Acceptance and Commitment Therapy

Acceptance and commitment therapy (ACT) is a CBT-based intervention that encourages people to accept their feelings instead of trying to change them. It incorporates mindfulness and other practices that help people experience their emotions more deeply without believing in or reacting to them. It can show people how to separate their sense of self from the ways they think and act, giving them the freedom to act in ways that don’t match their inner states.

In severe and persistent mental illnesses like schizophrenia, it is difficult, if not impossible, to control psychological processes, and trying to do so can increase instead of reducing distress. Acceptance and commitment therapy for psychosis works by encouraging people to make external changes that promote internal change instead of the other way around.

This therapeutic intervention has been shown to be especially effective for people with psychotic disorders, cutting rates of rehospitalization in half.

Coordinated Specialty Care

Coordinated specialty care (CSC) has been shown to be the most effective intervention for early psychosis. It is a set of different interventions carefully selected to address different symptoms and aspects of a person’s life. The six components of CSC are:

  • Case management
  • Family support and education
  • Psychotherapy
  • Medication management
  • Supported employment and education
  • Peer support

This suite of services helps people with psychotic disorders to experience improved family relationships, increased social connection and more consistent symptom management. Many case managers also refer clients to services needed to address other issues like medical problems.

The extent to which CSC improves a person’s quality of life is related to how quickly they start receiving care. The interconnected services of CSC provide support that can allow an individual to respond to changes in their condition quickly, helping prevent rehospitalization and other potential consequences of symptom recurrence.

Family and Group Therapy

Family and group therapy provides some of the same interventions as individual therapy in a group context that facilitates learning and peer support.

In family therapy, families can learn how to change patterns of communication or behavior that can increase stress and worsen outcomes for people with psychotic disorders. Family members can gain insight into how their loved one feels and learn how to support one another.

In group therapy, clients can connect with one another in ways that reduce shame and feelings of isolation, as well as learn effective ways to cope and manage symptoms from their peers. Group therapy is commonly incorporated into integrated interventions for psychosis-like CSC.

Treatment for Psychosis and Co-Occurring Conditions

Since psychotic disorders manifest in complex ways, many interventions used for them already incorporate multiple treatment modalities. This makes it easier to address co-occurring conditions.

Case managers can refer clients with psychotic disorders to additional treatment or to supportive services as needed, and psychiatrists can adjust medication regimens to address new symptoms or comorbid conditions.

Psychosis and Addiction

The frequency with which people with psychotic disorders have co-occurring substance use disorders is high. Research shows that as many as three-fourths of people with psychotic disorders also have a substance use disorder at some point in their lifetimes.

Typically, substance use and psychotic disorders are treated with separate but integrated services. This means people with dual diagnoses see different clinicians that are part of the same treatment team. In integrated approaches, therapists, psychiatrists, case managers, and other team members communicate with one another and coordinate interventions.

People with co-occurring disorders usually participate in both mental health and substance use treatment groups. Individual therapy often incorporates motivational enhancement approaches that are more effective for people with dual diagnoses. Sometimes, medication management is used to address both psychotic and substance use disorders through the use of replacement or agonist medications like buprenorphine and naltrexone.

Due to the intense functional impairments that arise in the acute phase of psychotic disorders, it is essential that people find the right services to address them, especially when they have co-occurring disorders.

If you or someone you know deals with drug or alcohol abuse alongside psychosis or another mental health disorder and is looking for this kind of treatment, contact The Recovery Village today. A representative can talk to you about services that can prevent hospitalization and promote a good quality of life for people with dually-diagnosed disorders.

Treatment for Psychosis
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