Ongoing research is revealing that specific combinations of medications can effectively treat dissociative disorders, especially when they are comorbid with other psychiatric disorders.

Dissociative disorders are not as well understood as many other psychiatric conditions. They are more controversial, and some clinicians have even questioned whether they exist. Dissociative disorders are hard to detect and underdiagnosed, and as a result of these and other factors, there is no clear clinical consensus on the best treatment protocol for dissociative disorders. However, this is beginning to change. As mental health professionals develop a better understanding of the effects of trauma on the brain, they gain insight into the psychiatric conditions linked to it. This is especially important for dissociative disorders, which are now much better understood as conditions that develop in response to trauma. Clinicians are uncovering g that these once-mysterious disorders not only exist as distinct clinical phenomena but have shared features and respond well to the right treatments.

Medications for Treating Dissociative Disorders

No psychiatric medications directly treat the symptoms of dissociative disorders. However, ongoing research is revealing that specific combinations of medications can effectively treat dissociative conditions, especially when they are comorbid with other psychiatric disorders. By treating other underlying conditions that trigger dissociative symptoms, dissociative conditions are improved as well.


Most people who have a dissociative disorder also have another psychiatric condition. As dissociative symptoms often develop in response to overwhelming emotional stress or pain, worsening depression and anxiety can trigger deeper and longer periods of dissociation.

Antidepressants can stabilize mood and reduce intrusive symptoms that trigger dissociation. Studies show that a combination of selective serotonin reuptake inhibitors (SSRI), a specific kind of antidepressant medication, and lamotrigine, an anticonvulsant and mood stabilizer, is an effective treatment for dissociative disorders, especially depersonalization-derealization disorder.

Anti-Anxiety Medications

Anxiety and dissociation are closely related. Both develop as responses to stress, trauma and chaos, and each can trigger the other. Treating anxiety symptoms can reduce the severity of dissociative symptoms. Some anxiolytic medications reduce hyperarousal and the intrusive symptoms of dissociative disorders. SSRIs are also commonly used to treat anxiety and are good choices for people with dissociative disorders. Benzodiazepines are typically contraindicated because they typically exacerbate dissociation.

Anti-Psychotic Medications

Dissociative disorders are not psychotic disorders, and psychotic symptoms are rare in people with these disorders. Even so, antipsychotic medications can be used to treat dissociative disorders, just as they are used to treat a wide range of non-psychotic psychiatric disorders. Atypical antipsychotic medications have been found to stabilize mood and to reduce anxiety and intrusive symptoms in people with dissociative disorders.

Therapy for Dissociative Disorder

While medications can be used to treat dissociative disorders, therapy is more commonly recommended as the best intervention. Different types of therapy address different aspects of dissociative disorders, and particular combinations of therapy modalities can be especially effective. Many modern therapists incorporate multiple treatment modalities in their work with clients for this reason.

Cognitive Behavioral Therapy

Research shows that cognitive behavioral therapy (CBT) is one of the most effective therapy modalities overall. It is especially effective to reduce the severity of a wide range of psychiatric symptoms. A primary focus of CBT is identifying negative or inaccurate thoughts and beliefs that drive painful emotions and maladaptive behaviors.

Specifically, in the case of dissociative disorders, CBT focuses on addressing obsessive thoughts that exacerbate derealization and on developing behaviors that counteract or distract from these thoughts. Behavioral treatment can also incorporate grounding techniques to counteract disembodiment and other dissociative symptoms.

Dialectical Behavioral Therapy

Dialectical behavioral therapy (DBT) is a therapy style that was developed to treat borderline personality disorder. It incorporates elements of CBT, like identifying emotional triggers, as well as mindfulness practices that can improve distress tolerance and emotion regulation.

Given those borderline personality traits and dissociative symptoms often co-occur, it makes sense that DBT has been found to be effective for both. The mindfulness techniques used in DBT, which include meditation, breathing exercises, and additional self-soothing techniques, can counteract dissociative symptoms like depersonalization. Validation combats derealization by acknowledging the reality of a person’s emotional responses.

Psychodynamic Psychotherapy

Psychodynamic psychotherapy is an older and more traditional form of therapy based on the work of pioneering figures like Sigmund Freud and Carl Jung. In this type of therapy, a person explores the effect of their past on their present, focusing on formative childhood experiences and a person’s relationship with their parents.

The main concept behind this style of therapy is that many negative behaviors developed as adaptations to stressful circumstances in childhood. To change these behaviors, a person must develop insight into their origins. Otherwise, emotional reactions remain unconscious. While this style of treatment has fallen out of fashion, it can still be an effective approach, especially for people with histories of trauma.

In the case of dissociative disorder therapy, psychodynamic psychotherapy can help people address and resolve underlying conflicts that drive dissociative symptoms. By gaining insight into the origins of their aversion to certain emotional states, they learn the deeper causes behind their dissociation. They become able to experience emotions they had previously found intolerable and from which they had dissociated.

Eye Movement Desensitization and Reprocessing (EMDR)

Eye movement desensitization and reprocessing (EMDR) therapy uses a novel technique in which the person receiving the treatment practices repetitive eye movements while revisiting a difficult memory to reprogram their response to that memory. The development of EMDR  as a way to treat trauma and has been shown to be effective for people with trauma histories and trauma-related disorders.

In a way, EMDR acts like a synthesis of CBT and psychodynamic therapy. Patients delve into memories like they would in psychodynamic psychotherapy and learn to reframe them as they would in CBT or DBT. This helps them develop different and less charged ways of reacting to these memories, often by forming new beliefs about them.

Treating Dissociative Disorders and Co-Occurring Disorders

It is rare for someone with a dissociative disorder not to have comorbid conditions, especially depression or anxiety. The most successful treatments for dissociative disorders address these co-occurring symptoms and conditions as well as unresolved trauma.

A special concern in dissociative disorder treatment is co-occurring substance use. It is not uncommon for people with trauma-related disorders to use substances as a form of self-medication. They may use substances to push away traumatic memories, soothe anxiety or even induce dissociation.

The combination of dissociation and substance abuse can be dangerous. Untreated psychiatric symptoms can cause substance dependence to develop quickly and intensely. In turn, substance use can exacerbate dissociative symptoms and comorbid anxiety and depression. In substance-induced dissociative states, people can feel so disconnected from the consequences of their actions that they become extremely self-destructive.

Related Topic: Aversion therapy

If you or someone you know is struggling with a substance use or co-occurring disorder dissociative disorder, help is available. At The Recovery Village, a team of professionals can create an individualized treatment plan to suit your needs. Call and speak with a representative to learn more about which program could work for you.

a woman in a business suit posing for a picture.
Editor – Nicole LaNeve
Nicole leads a team of passionate, experienced writers, editors and other contributors to create and share accurate, trustworthy information about drug and alcohol addiction, treatment and recovery for The Recovery Village and all Advanced Recovery Systems sites. Read more
a woman wearing glasses sitting in a chair.
Medically Reviewed By – Stephanie Hairston, MSW
Stephanie Hairston received her Bachelor of Arts degree in Psychology and English from Pomona College and her Master of Social Work degree from New York University. Read more
Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.