How Long Does Gralise Stay In Your System?

Gralise is a form of gabapentin. Gralise is not interchangeable with other versions of gabapentin. It is pharmacokinetically unique compared to other types of gabapentin and requires a different dose schedule. The metabolism of Gralise and gabapentin is unique compared to most other oral medications. Gralise is not processed by the liver, allowing it to pass through the body relatively quickly. The drug takes approximately 18 to 22 hours to be eliminated by the body.

Gralise How Long Does It Stay In Your System?

Gralise is used to treat pain caused by healing nerves following a case of the shingles. Shingles are more common among the elderly. They’re caused by an infection of herpes zoster and are characterized by a painful skin rash. As the damaged skin heals, it can be extremely painful. Gralise blocks the activity of nerve endings in the damaged skin, thereby reducing pain.

Some patients have thoughts of suicide when taking Gralise. Talk to your doctor immediately upon the onset of suicidal ideations. Share with your doctor if you have any history of kidney malfunction. Gralise is processed entirely by the kidneys. Treatment with Gralise will need to be closely monitored and doses coordinated with dialysis for patients with renal failure.

Gralise can cause drowsiness and poor coordination. Patients should not drive or operate machinery while taking Gralise. Mothers who are pregnant or breastfeeding should avoid treatment with Gralise. Gralise is present in both the placenta and breast milk.

Gralise How Long Does It Stay In Your System?

Gralise is not a commonly misused drug, except among patients who have a history of substance misuse. Gralise is not found in other drugs. However, people who are addicted to other medications such as opioids are known to combine them with Gralise or other forms of gabapentin. When combined, the pain-relieving effects of both drugs can increase.

The exact mechanism of Gralise is not yet fully understood. Gralise is thought to modulate the pain response by affecting the way the central nervous system processes calcium. Another possible explanation is that Gralise halts the formation of new synapses. Synapses are the areas on the outside of neurons that communicate with other neurons through chemical messengers.

The elimination half-life of Gralise and other forms of gabapentin is between 1.15 to 1.6 days. It’s safe to assume that after approximately two full days following ingestion Gralise is entirely excreted from the system. However, in many patients with poor health or renal impairment, clearance time can range from several days to a week. Gralise does not bind to proteins and has a clearance rate of 190 ml/min. 50 percent of Gralise is cleared from the system within five to seven hours.

Several factors influence the amount of time that Gralise stays in a patient’s system. These include dose, patient age, the patient’s body mass, urinary ph (level of acidity) and the health of the kidneys. Kidney health is the most influential factor because the kidneys are entirely responsible for processing Gralise. These factors can either speed up or delay the rate of Gralise excretion.

In healthy patients, Gralise takes between 18 and 22 hours to be entirely cleared from the system. Individuals with compromised renal (kidney) health can take significantly longer to process the drug. In patients with diseased kidneys, the excretion time frame of Gralise can take up to 136 hours. For individuals on dialysis, the clearance rate of Gralise can increase to 3.5 hours.

Because Gralise is not metabolized by the liver, its primary route of excretion is through the kidneys. Because of not being metabolized by the liver, no metabolites of the drug are present to bind to other sites in the body. This makes the urine the most reliable way to test for Gralise.

Gralise can also be tested for in the bloodstream, although its detection via this method is less consistent. Blood detection rates increase dramatically in patients with renal impairment. This is due to that fact that the processing of Gralise is significantly slower in individuals with kidney failure. Plasma concentrations of Gralise are increased in these patients, as are the drug’s therapeutic, pain-relieving effects.

Gralise can be detected in hair follicles in people who have been taking Gralise for a long time. Detection in hair follicles is the most accurate way to determine when the patient took their last dose.

If you or a loved one is struggling with substance use disorder, don’t delay. Go online to or call 24/7 to our toll-free hotline at 855-548-9825 to learn more about the road to recovery. We can help you overcome your addiction today.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.