Doral Withdrawal and Detox

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Quazepam, a generic drug marketed under the brand name Doral, is a benzodiazepine. Compared to other drugs in this class, it is long-acting. Doral and quazepam are typically prescribed to treat insomnia and to help overall sleep induction and maintenance. Doral has anticonvulsant and hypnotic properties. Unlike other benzos, Doral selectively activates specific GABA receptor sites, rather than all parts of the brain. Doral works only on the GABA receptors that control sleep. This means Doral has a lower potential for abuse, overdose and dependence compared to other drugs in the benzo class. Doral also has fewer overall side effects than similar benzodiazepines. For example, Doral use results in fewer incidents related to amnesia and problems with motor coordination.
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While Doral and quazepam are known to have a lower risk profile than many other similar benzodiazepines, they not entirely risk-free. Some of the main side effects of this prescription medicine include cognitive and performance impairment and daytime sleepiness. Doral also carries the risk of addiction. With longer-acting benzos like Doral, the risk of addiction is reduced but still exists.

Another consideration is quazepam tolerance. Tolerance occurs when a person needs higher doses of a drug or prescription medication to get the same effects. With benzodiazepines, many people develop a tolerance quickly, even within a few weeks of taking the drug. Tolerance tends to occur more slowly with quazepam or Doral, but it can occur. When people have a drug tolerance, they also often have a dependence. Physical dependence is separate from addiction.

Physical dependence occurs when someone’s body and brain have adjusted to the presence of a substance. The body and brain then view that substance as “normal.” When someone attempts to stop using the substance suddenly, they may go through withdrawal. Withdrawal symptoms can be both physical and psychological. With most benzodiazepines, the most severe withdrawal side effects are described as rebound symptoms. Rebound symptoms are what the drug was originally used to treat. During withdrawal, these symptoms often come back and are more severe than they were before the person began taking the drug. As an example, Doral is often prescribed for insomnia. Rebound withdrawal symptoms would mean a user would have worsening insomnia after stopping the medication.

While rebound withdrawal symptoms are possible with Doral, the pharmacology and chemical makeup of this drug ensure that the risk is low. Overall, Doral has a longer half-life than most other benzodiazepines. Even if someone is physically dependent on Doral, the withdrawal symptoms are likely to be less severe than they would be with something like Xanax.

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If a user is physically dependent on the drug, Dural withdrawal is possible. This is called benzodiazepine withdrawal syndrome, and it can be severe. In animal studies, high doses of quazepam administered for long periods of time led to severe withdrawal. Since Doral is a long-acting benzo, the withdrawal period can also be longer than for short-acting drugs. Some people experience Doral withdrawal symptoms for 90 days or more. The most common Doral withdrawal symptoms include

  • Irritability
  • Sleep problems
  • Anxiety, tension or panic attacks
  • Tremors
  • Concentration problem
  • Nausea and vomiting
  • Headache
  • Muscle pain
  • Changes in perception
  • Drug cravings

Over the long term, prolonged Doral withdrawal symptoms can include hallucinations, psychosis, seizures and an increased risk of suicide. These symptoms are very serious and can be deadly. A medical Doral detox is recommended, especially for people who are long-term or heavy users of the drug. During a medical detox, a professional team can manage the benzodiazepine withdrawal symptoms as they occur. A medically-supervised detox can also make the patient more comfortable, and more likely to successfully detox.

If you or your loved one is struggling with quazepam, benzodiazepines or any substance, please reach out to The Recovery Village. If you want more information about substance use disorder, we’re here to help.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.