How Long Does Doral Stay in Your System?

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Prescribed for insomnia, Doral is the brand name of quazepam. Quazepam is classified as a benzodiazepine, affecting GABA receptors in the brain. Unlike many other benzodiazepines, quazepam binds only to specific GABA receptors that influence sleep. In this way, Doral has a lower risk profile than other benzos. There is also a lower risk of addiction and dependence, although these scenarios are still possible. Research has shown Doral tablets can significantly reduce total wake time and increase sleep time. The measures of sleep (e.g., how long it takes to fall asleep, the duration of sleep, the number of times a person wakes up in the night, the tendency to wake up early in the morning and sleep quality) all tend to improve with the use of Doral.
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Before looking specifically at how long Doral stays in your system, what about benzodiazepines in general? Understanding how long specific drugs can stay in your system is important for a number of reasons. First, it can help avoid dangerous or deadly drug interactions. Accidental overdoses can occur when someone takes drugs simultaneously or too close together. For example, if someone took a benzodiazepine and then an opioid before the first drug cleared from their system, that person could experience profound respiratory depression.

Someone dependent on benzos might want to know how long the drug will stay in their system to determine when withdrawal symptoms will begin. Benzos can also show up in urine drug screens, which can be administered for employment purposes. Individual drugs within the benzodiazepine class can be short- or long-acting. Long-acting benzos include Xanax and Klonopin. Librium is intermediate-acting, and Halcion is considered short-acting.

Quazepam is selective for specific type 1 benzodiazepine receptors. As a result, it acts similarly to drugs like zolpidem. Quazepam doesn’t have muscle-relaxant properties, which is unique among other drugs in the benzo class. Doral has a half-life of 25 hours, which is considered very long among benzos. This means that within 25 hours, the average person’s body will have eliminated half the dose of Doral they took.

There are also specific metabolites of Doral with average half-lives of 28 and 79 hours. Peak blood levels of Doral usually occur within 1.75 hours after a dose is taken. According to the FDA, after taking a dose of quazepam, around 31% will show up in the urine after five days. The FDA also states that steady levels of quazepam show up in people after taking the drug for seven consecutive days. The elimination half-life of quazepam in geriatric users is double that of young adults.

While the long half-life of Doral and quazepam are beneficial in terms of reducing the risk of addiction and dependence, there are downsides as well. For example, with long-acting drugs like Doral, people are more likely to experience cognitive impairment during waking hours. Additionally, negative interactions with psychoactive drugs are more likely since the drug stays in the system for so long. On average, Doral stays in a person’s system for around 50 hours, and certain metabolites of the drug can show up in urine tests for longer than that.

Do you have questions about benzodiazepine abuse or addiction? If so, contact The Recovery Village. We can provide you with the answers and help you’re searching for.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.