Dolophine How Long Does It Stay in Your System?

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Dolophine is a brand name, synthetic opioid medication -also known as methadone hydrochloride in its generic form. Methadone is used in the treatment of opioid dependence and severe chronic pain that requires continuous pain management. Dolophine can take up to five days to build up to maximally effective levels in the body. The terminal elimination half-life of Dolophine is anywhere from 8 to 59 hours. Actual elimination times vary according to each patient’s unique metabolic factors.

Saliva tests can detect Dolophine for up to 10 days following the time of ingestion. Hair follicle screenings can test positive for up to 90 days, urine tests for up to seven days, and blood tests for up to three days.

Dolophine How Long Does It Stay in Your System?
Dolophine, like all opioids, is a highly addictive drug. Its use should be avoided if possible. Dolophine should not be used to treat transient pain that will pass within a few days. It is only indicated for the treatment of around-the-clock pain.

Dolophine can be taken as maintenance therapy for the treatment of opioid dependence. Dolophine is ideal for helping patient to wean off opioids due to its long duration of action and relatively mild withdrawal symptoms.

Dolophine is classified as a Schedule II controlled substance in the US under the regulation of the Federal Drug Administration (FDA). As of 2014, production was limited to approximately 31,000 kilos for sale for standard methadone, and 38,000 kilos for sale for methadone intermediate. Dolophine is a Schedule I substance in Canada and is illegal in Russian, even for therapeutic use.
Dolophine How Long Does It Stay in Your System?
A high percentage of opioid-related deaths involve the concomitant use of benzodiazepines (Xanax). Other substances that are abused recreationally with Dolophine include other opioids, non-benzodiazepine sedative/hypnotics, anxiolytics, MAO inhibitors, and alcohol. These substances compound the adverse effects of the drugs and increase the likelihood of fatal overdose.
Dolophine and other central nervous system depressants suppress the respiratory drive by preventing the brain from recognizing toxic carbon dioxide levels. The result is that the patient’s body remains unaware of the need to breathe -leading to cardiovascular failure, pulmonary edema, hypoxia, and various other life-threatening complications.

Dolophine achieves its pain-relieving effects by binding to opioid receptors. By binding to these receptors, Dolophine reduces the patient’s perception of pain.

Dolophine has a mean terminal elimination half-life of 22 hours. This can range anywhere from 8 to 59 hours, depending on the patient. Longer elimination times typically occur in opioid-tolerant individuals. The metabolism rates of Dolophine can vary by a factor of 100 between individual patients.

The half-life of Dolophine differs from its duration of action. Dolophine can continue to be effective for up to 30 hours following the time of ingestion. In opioid-tolerant patients, the average metabolic half-life of the drug is 24 hours. In patients whose bodies are not adjusted to processing opioids, the average metabolic half-life is 55 hours. It can take up to 190 hours to fully metabolize the drug in some patients.

Several factors influence the length of time that it takes to clear Dolophine from the body. The primary factor is the duration and frequency of use. Patients who have been taking Dolophine for a long time will take longer to eliminate the drug than individuals who recently began treatment.

Age, weight, body fat percentage, physical status, kidney and liver function, and genetic predispositions all impact the rate of excretion. Certain genetic mutations result in elevated plasma concentrations and extended clearance times. In general, heavier patients take longer to process Dolophine and are more tolerant of higher doses. Smaller patients tend to require lower doses and metabolize the drug at a faster rate.

Most blood tests are capable of detecting Dolophine use for up to three days following the time of the last dose. Urine screenings may test positive between 24 hours and seven days, and saliva tests can last up to 10 days. As with all substances, hair follicle tests can detect opioid use for up to 90 days following the time of ingestion.

If you or someone you know is struggling with drug or alcohol abuse, The Recovery Village is here to help. Visit us online at or call anytime, day or night, at 855-548-9825 for more information.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.