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Conzip achieves its pain-relieving effects by activating opioid receptors in the body and inhibiting the reuptake of the neurotransmitters norepinephrine and serotonin. The exact mechanism of action of Conzip is unknown. Conzip is converted into desmetramadol in the body. Desmetramadol is an active metabolite of tramadol, and it’s a more potent opioid.
Conzip should not be administered to patients who are at risk of suicide. The amount of Conzip necessary to overdose depends on several factors. In general, patients should not exceed 300 mg of any tramadol product in a 24-hour period.
Conzip is considered equally potent when compared to codeine and pethidine and is one-tenth as strong as morphine.
Common side effects of Conzip include nausea, dizziness, sweating and itching. These types of symptoms are common among most opioids.
Conzip is a powerful central nervous system depressant. It suppresses the subconscious instinct to breathe by acting on the brainstem. During an overdose, the brainstem may lose its ability to analyze carbon dioxide levels in the blood. Under normal circumstances, the brainstem triggers the lungs to breathe when carbon dioxide levels become elevated. In the event of an overdose, this mechanism becomes disrupted, potentially leading to toxic carbon dioxide levels, oxygen deprivation, coma and death.
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Decreased levels of consciousness are described as somnolence progressing to stupor or coma. The individual may deteriorate rapidly from responding in full sentences to being entirely unaware of their surroundings.
Other clinical presentations of acute Conzip overdose include skeletal muscle flaccidity, pulmonary edema, heart arrhythmias, cold and clammy skin, bradycardia (slow heart rate), airway obstruction and hypotension (low blood pressure).
Patients should not exceed more than 300 mg of Conzip in a single day. Non-opioid tolerant patients should start with a dose of 100 mg per day. This dose can be increased by increments of 100 mg every five days.
Oxygen therapy will likely be administered to help support oxygenation and address the onset of pulmonary edema. Vasopressors may be used to manage cardiovascular depression. In the event of heart arrhythmias or cardiac arrest, advanced life-support measures including CPR and shock treatment may be necessary.
Naloxone should not be administered unless clinically significant respiratory depression is evident. The premature administration of naloxone can make the patient’s condition worse. The risk of seizures increases upon administration of naloxone as treatment for Conzip overdose.
Several doses of naloxone may be needed in severe overdose cases. Intervals of two to three minutes should be allowed between doses. The duration of naloxone is significantly shorter than that of Conzip. The patient should be monitored closely for the first 24 to 48 hours following administration for the return of potentially life-threatening respiratory depression. In opioid-dependent patients, the administration of naloxone can precipitate the onset of severe post-acute opioid withdrawals.
If you or someone you love is struggling with an opioid misuse disorder, The Recovery Village is available to answer any questions you may have. Visit them at www.TheRecoveryVillage.com or call them toll-free at 855-548-9825 for more information about recovery resources in your area.
Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.