Conzip is a long-acting opioid medication. Like other opioids, it can cause dependence and addiction. Thankfully, medical detox and rehab are available.

Conzip is the brand name for tramadol extended-release capsules. Conzip may be prescribed for a variety of conditions that require around-the-clock pain management.

Conzip and other forms of tramadol have the potential for abuse and addiction. Abusing medication means taking it when it isn’t prescribed to you or in a way other than how it was prescribed. Addiction, also known as a substance use disorder, is a condition where a person continues to use a drug despite damage to their relationships, health, and finances.

Conzip Addiction

Conzip is a Schedule IV controlled substance in the U.S. under the Federal Drug Administration (FDA). It is illegal to possess it or use it without a prescription.

Taking opioids like Conzip in a way other than how they were prescribed may cause adverse effects. Long-acting opioids like Conzip have a high risk of overdose and death when they are abused.

Over time, tolerance can develop to Conzip. Tolerance is when more of the drug is required to achieve the same effect. Tolerance is normal when taking chronic opioids, so if someone develops a tolerance while taking Conzip as directed, they should let their doctor know it isn’t working as well.

If someone abuses Conzip, they may gain a tolerance, requiring them to take higher dosages to achieve the same positive effects. However, increased dosages also lead to higher rates of side effects and a greater chance of addiction.

Conzip, like all opioids, can be highly addictive. Individuals with a family history of substance use disorder are typically more prone to developing an opioid use disorder, but all patients are susceptible to developing opioid dependency.

If you are worried that you or someone you know may be addicted to Conzip, look for these signs:

  • They take the drug more often or in ways other than prescribed, like injection or snorting.
  • They mix Conzip with other substances of abuse.
  • They lose interest in things such as food, friends, and work.
  • Their personality may change.
  • They switch doctors constantly to receive higher dosages.

It’s important to stop Conzip misuse early to decrease the severity of withdrawal symptoms and possibly switching to stronger drugs like heroin.

What is Conzip?

Conzip is an analgesic opioid that’s used to treat moderate to severe chronic pain. It is an extended-release formula of the drug tramadol. Extended-release medications carry a higher misuse potential due to their generally higher drug content.

Conzip is roughly one-tenth as powerful as equivalent doses of morphine and is equal in potency to codeine and Demerol (brand name of meperidine). When taken by mouth, its effects begin within a few hours but may take a few days to begin working.

Conzip was approved by the FDA as an extended-release oral capsule in 1995 for once daily usage. Doctors try to avoid prescribing Conzip and will only do so when other non-opiate pain medications have failed.

The time-released feature of Conzip can be bypassed by crushing the tablet to snort or inject it. This greatly increases the risk of severe respiratory failure and fatal overdose.

How Is Conzip Used?

Conzip is meant to be taken once every 24 hours by mouth. To lower the chances of addiction, always take it as instructed by a doctor and never exceed the daily dosage.

The minimum effective dose should be used to reduce the risk of adverse effects when taking Conzip. Conzip is not indicated for the treatment of short-term pain.

Crushing, snorting, or chewing the opioid can cause adverse reactions and possibly result in an overdose. Extended-release narcotics are meant to provide long-term pain management by releasing the drug slowly. If the opioid is crushed and snorted, Conzip will be absorbed by the body faster, increasing the possibility of side effects and overdose.

Signs, Symptoms & Side Effects of Abuse

Common side effects of Conzip include:

  • Respiratory depression
  • Lethargy
  • Fatigue
  • Drowsiness
  • Dry mouth
  • Headaches
  • Drowsiness
  • Dizziness
  • Nausea
  • Vomiting
  • Constipation
  • Excessive sweating
  • Itchiness
  • Low blood pressure
  • Faintness upon standing

Symptoms of opioid misuse include constricted pupils, lethargy, drowsiness, and chronic fatigue. The individual may consistently have difficulty staying awake during normal waking hours.

As their misuse develops, they may become physically dependent on Conzip. Physical dependence means that when a person tries to stop the drug, they experience withdrawal symptoms. The patient may engage in drug-seeking behaviors, such as visiting multiple doctors in search of multiple sources for increased drug use.

As opioid dependency progresses, the individual may begin to lose interest in activities that they formerly enjoyed. They may socialize less or switch friend groups in favor of people who have more direct connections to drug sources.

An estimated 4–6% of people who misuse prescription pain medications transition to heroin at some point.

Conzip Overdose

The primary symptoms of an overdose include severe respiratory depression, decreased level of consciousness, and constricted pupils. These three symptoms are referred to as the “opioid overdose triad.” Of these, respiratory depression is the most life-threatening.

As a powerful central nervous system depressant, Conzip suppresses the areas of the brain that control breathing. Under normal circumstances, the brainstem triggers the lungs to breathe. In the event of an overdose, this mechanism becomes disrupted and slows breathing to a dangerous level.

Pupils may become constricted (smaller), even when exposed to direct light. The individual may deteriorate rapidly from responding in full sentences to being unaware of their surroundings.

Other signs of an overdose include skeletal muscle flaccidity (loose and floppy limbs), pulmonary edema (excess fluid in the lungs), heart arrhythmias (irregular heartbeat) or bradycardia (slow heart rate), cold and clammy skin, airway obstruction and hypotension (low blood pressure).

Conzip comes in 100 mg, 200 mg, and 300 mg tablets. Daily doses of tramadol medications should never exceed 300 mg due to the risk of overdose and death. 

Conzip and Alcohol

Combining Conzip with alcohol can lead to severe breathing problems and other effects, including dizziness, drowsiness, difficulty concentrating and impaired judgment.

Do not drink alcohol while taking Conzip. 

Talk to your doctor about your alcohol habits and assess your ability to abstain from alcohol while using a prescription painkiller. If you cannot avoid alcohol during this time, discuss other pain relief options with your doctor.

Long-Term Consequences

Long-term use of opioids like Conzip can cause adrenal insufficiency. Adrenal insufficiency means a person does not produce enough of the hormone cortisol. Symptoms of adrenal insufficiency include chronic fatigue, headaches, and mood swings. Chronic opioid use can also worsen osteoporosis.

All opioids cause chronic constipation by slowing the muscles in the intestinal tract. Foods don’t digest as quickly, leading to an obstruction of the intestine. Other long-term health risks may include slow breathing, bradycardia (low heart rate), hypotension (low blood pressure) and syncope (fainting).

Conzip Withdrawal

Once someone stops taking their prescription, they may experience withdrawal symptoms. The intensity of withdrawal depends on the severity and length of misuse. Attempting to detox without medical supervision is dangerous, especially if the addiction was with long-acting medication, was long-lasting, or was with high doses of opioids.

Do not abruptly stop taking the drug without first speaking to a medical professional. Withdrawal symptoms can start as soon as 12–20 hours after your last dose of Conzip.

The length and severity of symptoms depend on a few different factors: how long the drug has been taken, the daily dosage, genetic factors, and how the withdrawal is handled (tapering vs. “cold turkey”).

Withdrawal Symptoms

Withdrawal symptoms vary per person. Not everyone will experience all withdrawal symptoms when stopping or tapering off an opioid, but here are some common symptoms:

  • Anxiety
  • Diarrhea
  • Hallucinations
  • Insomnia
  • Nausea
  • Pain
  • Piloerection
  • Rigors
  • Sweating
  • Tremors
  • Upper respiratory symptoms

Withdrawal Timeline and Symptom Duration

It can take two to three days for Conzip to exit the body entirely. Traces of Conzip may be found in hair follicle tests for up to 90 days following the time of the last dose. Urine screenings may detect Conzip for up to 40 hours, and saliva and blood samples can test positive for up to 24 hours following the time of the last dose.

Mild withdrawal symptoms can be managed with over-the-counter painkillers, anti-anxiety medication, anti-nausea medication, and anti-diarrheal medication. Severe withdrawal symptoms could require hospitalization to assist with the withdrawal process. Psychological counseling is also suggested while going through withdrawal.

You never have to go it alone. If you need help with your withdrawal, seek help.

Conzip Addiction Treatment & Detox

Those seeking help in overcoming addiction may benefit from the several resources and treatment programs offered through The Recovery Village. Medical detox is useful for those still taking the substance. Once detox is complete, a person can continue into treatment.

Conzip Medical Detox

Long-term use of Conzip makes it challenging for a person to stop using the drug. Withdrawal symptoms may encourage a person to continue using the drug because they are uncomfortable. The process of allowing the drug to clear from the body is called detoxification.

Detoxification is often the first part of recovery, and it is highly recommended to detox under medical supervision. If a person struggling with addiction attempts to detox alone, it can be dangerous and harmful.

For opioids like Conzip, the treatment team may suggest a medication-assisted treatment (MAT). MAT is a group of prescription drugs that prevent opioid withdrawal symptoms. They work by binding to the same locations in the brain as opioids, but to a lesser extent. MATs prevent withdrawal symptoms but do not cause euphoria. They can be taken on a long-term basis.

Conzip Rehab

After detoxification is complete, a person can begin treatment for a substance use disorder (SUD). SUD treatment can happen in an inpatient or outpatient setting. Some patients who need inpatient treatment will begin detox there and then start treatment once detox is complete.

Our team also addresses any co-occurring mental health disorders. Co-occurring disorders are when a person has a mental health diagnosis and substance use disorder simultaneously.

Inpatient Rehab
Those in inpatient rehab live on campus at one of The Recovery Village designated inpatient centers during their addiction treatment. This rehab program can be beneficial for patients who have developed a severe addiction or may find it difficult to recover while living at home due to the outside world’s distractions.

Outpatient Rehab
After completing inpatient rehab, patients begin outpatient rehab where they live at home while they come to The Recovery Village for scheduled treatment appointments.

Some patients with mild or moderate addiction may begin treatment with outpatient rehab and skip inpatient treatment entirely, depending on their situation and needs.

Choosing a Conzip Rehab Center

Choosing the rehab center that’s right for you or a loved one is an important step in your recovery journey. Set up a meeting with your doctor to discuss what you should look for in a center. Things to consider include how long you’ve been taking Conzip as well as your dosage.

The Recovery Village offers treatment programs across the country. Each rehab center is dedicated to your long-term recovery and health. We make sure all of our patients are comfortable during recovery and strive to meet their individual needs. Contact us to speak with an admissions specialist about treatment options that can meet your needs.

Read Next


What are opioids?

Man-made opiates are called opioids. Collectively, opiate and opioid derivatives of the poppy plant include morphinecodeineoxycodoneheroin, and many other opioid drugs.

While there is no major difference in their effectiveness, opioids are synthetic or partly synthetic drugs that act similarly to naturally-made opiates. With opioids, the active ingredients are synthesized by chemical processes.

However, because they are similar in how they affect the body and brain, the terms opiate and opioid are often used interchangeably. Now, when people say “opioid,” they are usually referring to any substance that is naturally or synthetically derived from the poppy.

All of these drugs can be abused and cause addiction to develop, even if they are prescription medications. Even when used as prescribed, tolerance and physical dependence are common and expected consequences of opioids.

What is an opioid overdose?

Opioid overdoses are extremely dangerous events that affect thousands each year. Overdoses occur when the amount or potency of opioids overwhelm the body, leading to a slow down of the heart and lungs. Among the current and former opioid users surveyed, 48% had gone to the hospital for an opioid-related emergency, and 37% overdosed without getting to medical care in time.

Though they survived these dangerous situations, many more did not: overdoses involving opioids led to nearly 50,000 deaths in 2019.

Some of the most common signs and symptoms of opioid overdose include:

  • Nausea and vomiting
  • Trouble speaking
  • Weak or slowed heartbeat
  • Clammy skin
  • Purple or blue fingernails and lips
  • Losing consciousness

Drug overdose can be fatal. If you suspect someone is experiencing an overdose, call 911 immediately. Do NOT be afraid to seek help. If you do not have access to a phone, contact Web Poison Control Services for online assistance.

Is Conzip safe to take while pregnant?

Opioids like Conzip are not safe during pregnancy unless your doctor specifically tells you to. Researchers from the Centers for Disease Control (CDC) and Boston University found that when mothers use opioids during the first two months of pregnancy, they were two times more likely to have a baby with a neural tube defect compared to women who didn’t use opioids during pregnancy.

Opioid use during pregnancy was also linked to a higher likelihood of hydrocephaly (a buildup of fluid in the brain) and gastroschisis (a birth defect of the abdominal wall). Congenital heart defects may be more likely with the use of opioids like Conzip during pregnancy.

Conzip Misuse During Pregnancy

If you’re pregnant and your doctor prescribed you opioids, speak with them if you have concerns. There may be other ways to treat your pain aside from using a prescription opioid like Conzip.

On the other hand, if you have been using Conzip or another opioid before becoming pregnant — whether by prescription or recreationally — there are different considerations. You may experience withdrawal symptoms if you try to suddenly stop taking Conzip while pregnant. Going through opioid withdrawal while pregnant can cause serious complications that may be more dangerous than the use of the drug itself.

It’s important that you speak openly and honestly with your doctor about your use of prescription opioids. Together, you can create a plan to gradually taper down your dosage or get help. Some pregnant women may also opt to go through a medically-assisted detox and addiction treatment program.

Will Naloxone Reverse a Conzip Overdose?

Yes. However, please check the regulations around naloxone in your state. Naloxone should only be administered to a person who is unconscious or unable to breathe after taking opioids.

In opioid-dependent patients, the administration of naloxone can precipitate the onset of immediate opioid withdrawals. Call 911 if you have given someone naloxone.

Can Conzip lead to NAS in newborns?

Conzip can cause babies to become opioid-dependent in the womb, leading to neonatal abstinence syndrome (NAS) after birth. NAS can occur after exposure to any opioid during pregnancy, including methadone, buprenorphine, heroin, and prescription pain medications. As the substance passes through the placenta, the baby can become dependent upon it.

The severity and specific symptoms of NAS depend on the amount of medication being used, how long it was used, and whether the baby was born full-term or premature. Symptoms will usually begin within one to three days after birth, but they may not appear for a week after birth in some cases.

Symptoms can include excessive or high-pitching crying, increased muscle rigidity, fever, and overactive reflexes. Tremors, convulsions, poor feeding, breathing problems, sleep issues, and slow weight gain are also possible. Babies born with NAS will usually have to stay in the NICU until the symptoms subside.

What are common street names for opiates/opioids?

People who abuse these drugs frequently refer to opioids using slang words and phrases to evade police attention. Some of the street names for a variety of opiates and opioids include:

  • H
  • Hammer
  • Skag
  • Gear
  • Smack
  • Horse
  • Elephant
  • Rock
  • Nose drops
  • Black tar
  • China white
  • White
  • Chinese H
  • White dynamite
  • Dragon
Why does long-term use of prescription opioids lead to addiction for many?

A study published in the journal Pharmacoepidemiology & Drug Safety (PDS) examined trends in prescription opioid use in the United States from 1999 through 2000, and from 2013 through 2014, and results were compared. Specifically, this study looked at long-term opioid use, which was defined as the use of prescription opioids for 90 days or longer.

In 1999-2000, 4.1% of adults were taking prescription opioid medications, and from 2013 through 2014, 6.8% of US adults were taking prescription opioids. The increase was mostly driven by an increase in the long-term use of prescription opioids, which increased from 1.8% of adults to 5.4%. Long-term use of opioids correlates with many negative health consequences.

Long-term use of opioids is associated with worse physical health, a higher incidence of benzodiazepine use, and higher rates of heroin addiction. Therefore, the study concludes, it is essential that doctors carefully weigh the risks and benefits of long-term opioid use in their patients before prescribing it.

A CDC study from 2017 reported that the sharpest increase in the likelihood of long-term dependency on prescription opioids came just five days after the initial prescription. Another spike in dependency was seen after one month. In general, however, the longer a prescription, the greater the risk of long-term addiction.

Long-term opioid use was also associated with other types of addictions. For example, the study published in PDS found a higher risk of alcohol abuse and heroin abuse among people who had been prescribed opioids for long periods.

2016 study published in Addiction Science & Clinical Practice reported that alcohol misuse among people in medication-assisted addiction treatment for opioid use disorder was common and was associated with a greater risk of death.


National Institute on Drug Abuse. “Opioid Overdose Crisis.” May 27, 2020. Accessed July 12, 2020.

Centers for Disease Prevention and Control. “Opioid Use and Neural Tube Defects.” June 1, 2018. Accessed July 12, 2020.

Centers for Medicare and Medicaid Services. “Opioid Oral Morphine Milligram Equivalent (MME) Conversion Factors.” August 2017. Accessed July 12, 2020.

Vertical Pharmaceuticals. “Conzip Package Insert.” 2017. Accessed July 12, 2020.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.