Palladone How Long Does It Stay in Your System?

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Palladone can take anywhere from two to three days to clear from the patient’s system. The average half-life of Palladone is approximately 18.6 hours. This is the amount of time it takes to reduce Palladone concentrations to 50% of active levels.

Several factors influence how long Palladone remains active, including age, size/weight, kidney and liver function, genetics, and drug tolerance.

Palladone is an extended-release version of the drug hydromorphone hydrochloride, a potent semi-synthetic opioid painkiller. Palladone is a hydrogenated ketone variation of the drug morphine. It’s available in 12 mg, 16 mg, 24 mg, and 36 mg doses. In the event of an overdose, an opioid antagonist like naloxone will likely be administered to the patient. Naloxone rapidly reverses the effects of Palladone by breaking its bond with opioid receptor sites in the body. The administration of naloxone can trigger the onset of severe opioid withdrawal symptoms.

In the US, Palladone is a classified as a Schedule II controlled substance. Its distribution is tightly regulated by the Federal Drug Administration (FDA). When taken recreationally, Palladone and other extended-release opioids have a higher likelihood of overdose than immediate-release capsules. This is because extended-release tablets have a higher drug content that’s intended to be released into the body gradually over a 24-hour period. Many people who abuse Palladone bypass the time release feature by crushing the tablet. The drug is then released into the system too rapidly and can result in an overdose.

Palladone How Long Does It Stay in Your System?

Opioids like Palladone are commonly abused with other central nervous system depressants. Palladone is often mixed with benzodiazepines, barbiturates, muscle relaxants, marijuana, and alcohol. Combining these substances with Palladone can lead to a potentially fatal depression of the patient’s respiratory drive.

Palladone is an opioid agonist. It reduces the patient’s experience of pain by binding to and activating specific opioid receptor sites in the brain. Palladone and other opioids have major effects on the central nervous system and gastrointestinal tract. Side effects of Palladone can include mental clouding, analgesia, mood fluctuation, cough suppression, euphoria, dysphoria, respiratory depression, constipation, pinpoint pupils, nausea, vomiting, and increased cerebrospinal fluid pressure.

Palladone has a half-life of 18.6 hours. Peak blood plasma concentrations are reached within 30 to 60 minutes of ingesting the drug. The time-release effects of Palladone are layered to allow for a rapid onset of peak concentrations, followed by a more gradual release over a 24-hour period of time. The steady dose released by Palladone is the equivalent of the immediate-release form hydromorphone hydrochloride that is given every six hours. Peak concentrations of immediate-release capsules are reached within 30 to 60 minutes and have a half-life of approximately 4.1 hours.

The absorption rate of Palladone is heavily dependent on pH levels in the body. Food intake has no significant impact on the rate of excretion from the body.

Palladone is not recommended for individuals with a history of liver failure. Patients with minor hepatic impairment may be considered for prescribing small doses of the drug. Palladone is primarily processed in the body by the liver, and impaired liver function is known to result in higher plasma concentrations and longer elimination times.

Poor kidney health may also affect elimination times, along with patient’s size and weight, drug tolerance, age, genetics, and alcohol consumption. Alcohol interferes with the liver’s ability to process Palladone.

Palladone metabolites have been found in urine and blood plasma in hepatocyte test systems. It takes roughly two to three days for steady-state plasma concentrations to be reached, and about the same amount of time to clear the drug from the system. Full studies of Palladone recovery times have not yet been conducted. However, full mass balance and recovery studies have been completed with the immediate-release version of the drug. Complete elimination of immediate-release hydromorphone takes approximately 24 hours from the time of the last dose. When the drug is consumed via intravenous administration, it has a clearance rate of about 1.66 L/hr. Palladone can be tested for in hair follicles within 90 days of the date of last use.

The road to recovery from substance abuse can be long and challenging. The Recovery Village is here to help. Visit us at or call toll-free at 855-548-9825.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.