Nucynta Overdose
Nucynta can be highly addictive and carries a risk of fatal overdose. It should not be taken along with other central nervous system depressants, including alcohol, benzodiazepines, antipsychotics, general anesthetics, tranquilizers, anxiolytics, muscle relaxants, non-benzodiazepine sedative/hypnotics, or other opioids.
Serotonergic drugs intended to treat depression should also be avoided. These include selective serotonin reuptake inhibitors (SSRIs) and tricyclics. MAO inhibitors should be avoided due to the risk of serotonin overload and respiratory depression.
Nucynta has a unique pharmacology that sets it apart from most other opioids. Nucynta activates opioid receptors and inhibits the reuptake of the neurotransmitter norepinephrine. By inhibiting the reuptake of norepinephrine, it increases its activity in the brain. Nucynta is similar in this way to tramadol, the difference being that tramadol inhibits the reuptake of serotonin instead of norepinephrine.
Nucynta comes in the form of an oral solution. The patient can experience pain relief approximately 30 minutes following the time of administration. Nucynta has a duration of action of four to six hours. Nucynta is comparable in strength to oxycodone but has significantly fewer side effects.

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Speak with an Intake Coordination Specialist now.352.771.2700Maximally constricted pupils are a trademark sign in nearly all opioid overdose cases. Pupils will refuse to dilate even to dramatic changes in light. In the later stages of overdose, oxygen deprivation will cause the pupils to fully dilate if left untreated.
Other signs of Nucynta overdose include cold and clammy skin, pulmonary edema, skeletal muscle flaccidity, hypotension, bradycardia (slow heart rate), atypical snoring, and partial or complete airway obstruction.
Multiple doses of naloxone may be necessary in cases of severe overdose. Intervals of two to three minutes should be allowed between doses. The patient will need to be closely monitored for the return of clinically significant respiratory depression due to naloxone’s relatively short duration of action. The use of naloxone can precipitate the onset of severe opioid withdrawals.
If you or someone you love is struggling with opioid misuse, The Recovery Village is available to answer any questions you may have. Visit us online at www.TheRecoveryVillage.com or call our toll-free hotline at any time, day or night, at 855-548-9825 to learn more about recovery options in your area. The road to recovery isn’t always easy, but the team at The Recovery Village promises to be with you every step of the way.
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Read the most frequently asked questionsSeeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help.
Your call is confidential, and there's no pressure to commit to treatment until you're ready. As a voluntary facility, we're here to help you heal -- on your terms. Our sole focus is getting you back to the healthy, sober life you deserve, and we are ready and waiting to answer your questions or concerns 24/7.
Speak with an Intake Coordination Specialist now.352.771.2700