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Infumorph should not be mixed with alcohol. The combined use of Infumorph and alcohol can increase the likelihood of opioid overdose and alcohol toxicity. Infumorph should not be taken in conjunction with serotonergic drugs such as selective serotonin reuptake inhibitors (SSRIs) used to treat depression.

Concomitant use of Infumorph and serotonergic drugs can result in serotonin syndrome. Serotonin syndrome is a state of serotonin overload that can lead to permanent psychosis and death in severe cases. Infumorph use should be discontinued if the potential for serotonin syndrome is suspected.

Infumorph should not be combined with mixed agonist/antagonist or partial opioid agonist pain relievers. These drugs produce a “ceiling effect” that may limit the effectiveness of Infumorph, precipitate withdrawals, and make it more difficult to accurately adjust doses. The use of MAO inhibitors should be avoided.

Adverse effects associated with Infumorph use include apnea, respiratory depression, respiratory arrest, depression, circulatory depression, shock, and cardiac arrest. Other complications include lightheadedness, nausea, vomiting, sedation, dizziness, and constipation. The risk of severe respiratory depression is greatest within the first 24 hours of the initial treatment. Patients should be closely observed for the formation of inflammatory masses at the injection site.

Infumorph Mixing It and Alcohol

Infumorph is a synthetic opioid that’s indicated for the treatment of severe chronic pain. Infumorph should only be administered when other milder forms of pain management have proved ineffective. The minimum standard dose of Infumorph should always be used.

Infumorph is a high-potency solution of morphine sulfate that’s intended for use in continuous microinfusion devices. Such devices administer medication through an injection site in the spinal cord. Infumorph is only intended for use in opioid-tolerant patients. Administering Infumorph to non-tolerant opioid patients greatly increases the likelihood of severe complications and overdose. Infumorph is free of preservatives, antioxidants, and other potentially neurotoxic additives.

Concomitant use of alcohol and Infumorph is rare considering that Infumorph is only administered in a hospital setting. The equipment used to administer the drug requires highly-trained professionals to operate. Medical staff would likely not allow the administration of Infumorph if alcohol was detected in the bloodstream due to the risk of complications.

Other formulations of morphine sulfate, however, are abused recreationally. Recreational abuse of morphine products can result in fatal overdose, especially when mixed with other central nervous system depressants like alcohol. The metabolism of alcohol and morphine conflict in the liver, leading to elevated plasma concentrations of morphine along with extended clearance times. The adverse effects of both substances are intensified when they are taken together.

Infumorph Mixing It and Alcohol

Infumorph should not be taken with mixed agonist/antagonist or partial opioid agonist pain relievers. The concomitant use of Infumorph, MAO inhibitors, serotonergic drug, and other central nervous system depressants should also be avoided. Life-threatening respiratory depression and serotonin syndrome are the primary risk factors associated with the combined use of these substances.

If you or someone you love is struggling with drug or alcohol misuse or abuse, The Recovery Village is here to help. Visit us online at or call our toll-free number at 855-548-9825 for more information.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.