Provigil How Long Does It Stay In Your System?

Provigil is intended to counteract narcolepsy and similar sleep disorders, so patients usually take 1/2 before breakfast and another 1/2 before lunch to benefit the most from the prescription. Modafinil will stay in your system about 82 and 1/2 hours after the last dose, depending on a variety of individual factors.

To determine how long Provigil will stay in your system, talk to your doctor.

If you are advised to stop taking modafinil, work with your doctor and inform him of any drugs you plan to take after stopping modafinil to avoid any interactions which may occur before the prescription leaves your system entirely.

Provigil How Long Does It Stay In Your System?

Provigil is the brand name for the generic prescription modafinil. It’s a eugeroic prescribed to treat narcolepsy and other sleep disorders. The drug is known as a dopamine reuptake inhibitor, which blocks the action of dopamine in your body by stimulating the release of orexin neuropeptides and histamine in your body.

Provigil doesn’t cure your sleep disorder, but it helps the brain manage the sleep/wake cycle. The medication is taken orally in the morning and, as with other prescriptions, carries with it a risk of side effects.

An off-label use for modafinil is for ADHD and to enhance learning abilities, although that’s not the primary intent of the prescription.

Possible common side effects associated with the use of modafinil include:

  1. Headache
  2. Nausea
  3. Nervousness
  4. Dizziness
  5. Difficulty sleeping

Serious side effects are rare but may occur, such as fast/pounding heartbeat, irregular heartbeat or mental changes. Contact your doctor right away if you experience any side effects at all, so you can decide together if modafinil is the right medication choice for your condition.

Modafinil is listed in the United States as a class IV controlled substance, which means it’s limited in usage and distribution because of the possibility of addiction. Provigil can only be prescribed by a qualified doctor who has determined this to be the best way to treat your condition.
Provigil How Long Does It Stay In Your System?

Modafinil isn’t contained in any other drug, only Provigil. Provigil is thought to have a low potential for misuse, but it is possible. Studies have shown that misuse of modafinil can lead to agitation, insomnia, anxiety, irritability, aggressiveness, confusion, nervousness, tremor, palpitations, sleep disturbances, nausea and diarrhea.

No overdoses of Provigil alone have been reported.

If you feel you or a loved one is misusing Provigil; however, don’t wait to get help. Go online to or call 24/7 to our toll-free hotline at 855-548-9825 to learn more about the road to recovery. We can help you overcome your addiction today.

Provigil bonds with the dopamine transmitter in the brain to act as a dopamine reuptake inhibitor, which, as mentioned, blocks the action of your dopamine by stimulating the release of orexin neuropeptides and histamine in your body.

There is a possibility of Provigil affecting your body by way of side effects listed in the prescription facts above.

Although there are no definitive answers as to the long-term effects related to the use of modafinil, there are some theories based on other prescriptions with similar effects. The thought is that long-term use of Provigil could permanently disrupt your sleep cycle because it’s artificially regulating when you sleep instead of letting your body sleep when it wants to. This could lead to non-restful sleep long term. Also, there’s a concern that long-term use could affect memory.

The half-life of any prescription is the amount of time it takes for that medication to lose half of its pharmacologic strength. The half-life of Provigil is approximately 15 hours.

Several factors play a part in how long modafinil stays in your system, which are:

  1. Dosage
  2. Amount of time on medication
  3. Individual physiology

Your doctor can help you figure out the approximate time frame Provigil will stay in your system. Inform your doctor of your complete medical history, so he or she can accurately help you.

Provigil isn’t something that drug tests would normally test for, and no false positives have been reported with this prescription. Since modafinil stays in your system for about four days, it’s likely that’s about the amount of time it can also be detected in your urine and blood. Medications tend to stay in your hair much longer than that, about 90 days, so be sure to inform your test administrator about any drugs you are taking or have recently taken. Doing so will ensure you receive the most accurate test results.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.