Lisdexamfetamine Withdrawal and Detox

Lisdexamfetamine is a psychostimulant drug. It’s most commonly known as the brand-name drug Vyvanse, and it’s available only by prescription. Lisdexamfetamine is used to treat ADHD symptoms, and also binge eating disorder. It’s considered to have a slightly lower addiction potential than Adderall. Despite the fact that it’s less addictive than Adderall, it is still a Schedule II controlled substance. This means that it has a high likelihood of both addiction and dependence. When someone is dependent upon lisdexamfetamine or Vyvanse and they suddenly stop using the drug, they will likely experience withdrawal symptoms. Common lisdexamfetamine withdrawal symptoms can include:

  • Anxiety
  • Concentration problems
  • Depression
  • Fatigue
  • Headaches
  • Irritability
  • Loss of motivation
  • Mood swings
  • Sleepiness

Most people who recreationally abuse lisdexamfetamine will experience a crash or “comedown,” as the effects of the drug start to wear off. This is because certain neurotransmitters in their brain are depleted at this time. The side effects of a lisdexamfetamine crash are similar to those of withdrawal, but it’s not exactly the same scenario. For example, someone can experience a lisdexamfetamine crash after using the drug only once, when they’re not dependent upon it. This crash effect happens with other amphetamines and prescription stimulants as well.

Actual lisdexamfetamine withdrawal isn’t typically life-threatening, but it can be uncomfortable. The specific lisdexamfetamine withdrawal timeline depends on various factors. These factors can include how long someone used lisdexamfetamine or Vyvanse, how much they usually used, and their metabolism rate. Other factors that influence the withdrawal timeline include age, gender, weight and whether or not other substances are also used. The half-life of Vyvanse is usually around 10 hours, so it can take around 50 hours or so, on average, for withdrawal symptoms to begin. The first phase of withdrawal is the crash. Following a crash, the actual withdrawal symptoms start. Symptoms of Vyvanse withdrawal can usually last anywhere from one to two weeks and, after that time period, they start to subside. Some people may experience psychological symptoms like low mood or depression for longer than two weeks.

When someone is prescribed lisdexamfetamine and they need to stop using it, they will usually follow a tapering-down schedule recommended by a physician. Tapering down the dose of lisdexamfetamine slowly is one of the best ways to manage or reduce withdrawal symptoms. It’s important for people to avoid trying to create their own tapering-down schedule. Not only can it still lead to withdrawal, but it can also cause severe symptoms. Withdrawing from any habit-forming drug should be done under the instruction and supervision of a medical professional.

Detox is usually the first step in addiction treatment. Patients need the drugs to be fully eliminated from their systems before they can begin actual treatment. With some drugs, such as alcohol and opioids, there are certain FDA-approved medications that can be given to manage withdrawal symptoms. This isn’t the case with stimulants like lisdexamfetamine. Instead, with stimulants, the symptoms are managed during detox as they occur. For example, a person might receive certain medications to treat sleep disturbances or psychological issues, such as anxiety or depression. During a supervised detox, patients are also monitored to make sure they’re healthy and safe as the drug leaves their system.

For someone who wants to participate in a supervised lisdexamfetamine detox, there are some key considerations. First, the detox center should be familiar with stimulant detox and treatment since the side effects and complications are different from other drugs. It’s usually best to opt for a professional detox center that’s part of a drug addiction treatment program as well. That way, the participant can detox, and then stay in the same facility as they move into addiction treatment. Many people who abuse stimulants have complicating factors that need to be addressed in a detox center as well. For example, people who abuse stimulants also often abuse other drugs as well. Polysubstance drug withdrawal can be more complex, and a detox center needs to be experienced in handling these scenarios.

To learn more about medical detox and addiction treatment, take the first step now by contacting The Recovery Village.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.