How Long Does Lisdexamfetamine Stay in Your System?

Lisdexamfetamine is a prescription stimulant drug, better known as the brand name drug Vyvanse. Lisdexamfetamine stimulates the central nervous system and impacts certain brain neurotransmitters, including dopamine and norepinephrine. It’s a prodrug and has a slower onset of action, making it slightly less addictive than other prescription stimulants like Adderall. Lisdexamfetamine is primarily prescribed for the treatment of ADHD symptoms, and it can be used in adults and children aged 6 years and older. Lisdexamfetamine is also used to treat binge eating disorder, however, it is not a weight loss aid. When someone takes Vyvanse, the drug is released at the same levels over time -rather than all at once, so it’s unique from Adderall and Ritalin.

Lisdexamfetamine has a lower abuse potential than other ADHD stimulant drugs, but abuse is still possible. All ADHD drugs are controlled substances in the U.S. Specifically, lisdexamfetamine is classified as a Schedule II drug. This means that while it currently has an accepted medical use currently in the U.S., there is still a high risk for abuse and dependence.

Stimulant drugs speed up processes in the central nervous system. When someone uses stimulants as prescribed, they aren’t likely to experience many side effects. However, when someone abuses them recreationally or uses large amounts, they may experience feelings of euphoria, increased focus and concentration, and false confidence. Frequently abused prescription stimulants include Adderall and Ritalin. The high that people experience from prescription stimulants can feel similar to the high from cocaine.

When someone takes lisdexamfetamine as prescribed for ADHD, it can help them focus and concentrate. It can also reduce hyperactivity and impulsiveness. When someone uses lisdexamfetamine recreationally, there is an increased availability of certain neurotransmitters in the brain like dopamine and norepinephrine. These levels are what create a euphoric high. Lisdexamfetamine can also lead to increased heart rate and blood pressure, dilated pupils, and suppressed appetite. People who use lisdexamfetamine often don’t sleep for long periods of time. Other effects of lisdexamfetamine can include irritability, increased motivation, and distortion of time. When the effects of lisdexamfetamine wear off, people may experience a crash. Symptoms of a lisdexamfetamine crash can include anxiety, physical and mental fatigue, depression, irritability and a decline in motivation. Lisdexamfetamine is classified as a prodrug. This means that it’s absorbed more smoothly than other ADHD drugs. This also reduces the likelihood of abuse.

The half-life of Vyvanse, the brand-name version of lisdexamfetamine, is estimated to be around 45 minutes to an hour, on average. That means that the primary parent drug of Vyvanse would be eliminated within anywhere from 4 to 5 ½ hours. Lisdexamfetamine is a short-lasting drug that is quickly eliminated from the system; however, lisdexamfetamine can leave behind longer-lasting metabolites that remain even when the parent drug is eliminated. Two metabolites left behind from Vyvanse are dextroamphetamine and L-lysine. These have higher half-lives than the parent drug of Vyvanse. The half-life of dextroamphetamine is between 9 and 11 hours, on average. This means that this metabolite could stay in the system for over two days or more. For most people, an entire dose of Vyvanse, including metabolites, would be eliminated from the system in less than three days.
With any drug, including lisdexamfetamine, there are certain factors that influence how long it stays in the system. While half-life and elimination times are estimates, factors like metabolism and age play a significant role. For example, a young person with a fast metabolism and no health problems is going to eliminate a drug like lisdexamfetamine more quickly than an older person, someone with a slower metabolism, or a person who has health conditions. Even temporary factors like hydration can influence how long it takes for a dose of lisdexamfetamine to be eliminated. Someone who is well-hydrated is going to have a faster urinary flow rate, so they will eliminate the drug more quickly.

While lisdexamfetamine might not show up in a standard drug screening, people often wonder how long it would show up in a specialized drug screening that looks for amphetamines. In a blood test, lisdexamfetamine could show up for anywhere from 8 to 24 hours after a dose was taken. In a urine test, lisdexamfetamine would likely show up for around three days. A hair test could show the use of lisdexamfetamine for a month or more.

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