Zohydro ER How Long Does It Stay in Your System?

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Zohydro ER is an extended-release formula of the synthetic opioid hydrocodone. Zohydro has an average terminal elimination half-life of eight hours. Hydrocodone is present at testable levels in the urine for up to four days following the time of the last dose. Saliva screenings may test positive for hydrocodone between 12 to 36 hours after the last dose is taken. As with all substances, hair follicle tests can screen for hydrocodone for up to 90 days following the time of the last dose. Blood tests can detect hydrocodone for up to 24 hours.

Zohydro ER How Long Does It Stay in Your System?

Zohydro ER is prescribed for the treatment of moderate to severe chronic pain. Zohydro ER is not indicated for the treatment of acute pain due to its slow onset time. In 2015, Zohydro ER was reformulated with special technology to make it more difficult to misuse. Nevertheless, many extended-release opioids can be taken as immediate-release by crushing the pill before ingesting, snorting, or melting and injecting it. Zohydro ER is now designed to turn in a viscous gel when it is crushed or dissolved in liquids. The hope is that this will cut down on Zohydro ER-related overdose cases.

Patients should be informed about the risk of adrenal insufficiency related to prolonged use of Zohydro ER. Adrenal insufficiency occurs when the adrenal gland is no longer able to produce an adequate amount of the stress hormone cortisol. Adrenal insufficiency is characterized by fatigue, nausea, vomiting, dizziness, anorexia, and low blood pressure.

Zohydro ER is classified as a Schedule II substance by the Federal Drug Administration (FDA). Zohydro ER gained FDA approval in 2015. The decision to allow manufacturing of the drug was controversial. Zohydro ER’s own review panel strongly voted against approving the drug due to the high potential for misuse that extended-release opioids carry. The formula advances mentioned above attempted to address this concern.

Zohydro ER should not be used recreationally. Off-label, unsupervised use of Zohydro ER greatly increases the risk of life-threatening complications and overdose. When Zohydro ER is used recreationally, it may be combined with other opioids and central nervous system depressants. Anxiolytics, benzodiazepines, non-benzodiazepine sedative/hypnotics, MAO inhibitors (MAOIs), tranquilizers, anticonvulsants, and alcohol should not be mixed with Zohydro ER. Doing so can lead to severe respiratory depression. Benzodiazepines like Xanax have become increasingly popular to abuse recreationally. The concomitant use of benzodiazepines and opioids are common in a high percentage of recreational opioid overdose cases.

Zohydro ER is a full opioid agonist. When it is taken at therapeutic doses, it interacts primarily with mu-opioid receptors in the body to reduce the patient’s perception of pain. At higher doses, it begins to interact with various other opioid receptors as well. The fact that Zohydro ER is a full opioid agonist is one of the reasons that makes it so dangerous. Full opioid agonists do not produce a “ceiling effect” as partial opioid agonists do. This means that there is no limit to how “high” the patient can feel by taking stronger and more frequent doses.

Zohydro ER has an average total plasma half-life of eight hours. When patients first begin treatment, it takes roughly five hours to reach peak concentrations. Maintenance doses are taken once every 12 hours. A steady state is reached after three days following the initial dose. Zohydro ER tends to result in lower maximum plasma concentrations than immediate-release formulas of the drug.

Zohydro ER is primarily eliminated by the kidneys. Patients with impaired kidney function are more likely to experience extended clearance times and elevated blood plasma levels of the drug. This places patients with poor kidney health at an increased risk of severe respiratory depression and overdose. Other factors that influence Zohydro ER elimination include the patient’s liver health, physical status, age, weight body fat percentage, and genetic tendency.

Hydrocodone may be detectable in saliva tests between 12 to 36 hours from the time of the last dose. Blood tests can detect hydrocodone for up to 24 hours. Hair follicle tests can screen for hydrocodone for up to 90 days following the time of the last dose. Hydrocodone may be present at testable levels in the urine for up to four days following the time of the last dose.

If you or someone you love is struggling with drug or alcohol dependence, The Recovery Village is here to help. You can contact us anytime, day or night, at 855-548-9825 or visit us online at www.TheRecoveryVillage.com to learn more about the path to recovery.

Zohydro ER How Long Does It Stay in Your System?
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