How Long Does Viibryd (Vilazodone) Stay In Your System?

Viibryd is an antidepressant that has a half-life on the longer side of antidepressants in the same category. This prescription is protein-bound and is mostly eliminated through protein enzymes, leaving only 1 percent to be eliminated through urine. Viibryd will stay in your system at least 140 hours after your last dose, depending on your personal factors described below.

Be sure, however, to let your doctor know you were taking Viibryd if he is considering an MAOI to treat your depression, as you shouldn’t take an MAOI within 14 days of taking vilazodone.

Viibryd (Vilazodone) Prescription Facts

Viibryd is the brand name for the prescription vilazodone, which is used to treat depression.

Depression is a condition that affects the world’s population. There are many antidepressants in the market, and they are divided into different groups, which take different routes to help relieve depression in a patient. The different antidepressant prescription groups are:

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants

Viibryd is an antidepressant in the SSRI category, which also has a partial serotonin receptor agonist and treats depression by altering the serotonin neurochemicals in the brain.

It may take a week or two to feel the full effects of vilazodone, and your doctor may gradually increase the dosage to full strength over time to decrease the likelihood of side effects. As with other antidepressants, you still may experience side effects from taking vilazodone. The most common side effects include diarrhea, dizziness, dry mouth, nausea and trouble sleeping.

Some more serious side effects to monitor are:

  • Numbness/Tingling
  • Tremors
  • Restlessness
  • Difficulty Concentrating
  • Confusion
  • Memory Problems
  • Weakness
  • Unsteadiness
  • Pounding Heartbeat

If you experience any of these side effects or have any undesirable changes in mood or behavior, contact your doctor right away. Do not abruptly stop taking vilazodone but work with your doctor to decrease the medication, as this increases the chance of side effects.

Viibryd (Vilazodone) Regulations

Viibryd is not regulated beyond other antidepressants on the market. The medication can only be obtained through a prescription from a qualified doctor who has determined, based on examination, that you will benefit from this SSRI in treating your condition.

Most Commonly Abused Drugs Containing Viibryd (Vilazodone)

Vilazodone can have adverse reactions to other medications and can lead to severe side effects when not taken as directed, but the prescription isn’t included inside other medications, and there are no reports that Viibryd causes any physical or psychological addiction.

If you feel you or a loved one is misusing Viibryd and is struggling, don’t wait to get help. Go online to or call 24/7 to our toll-free hotline at 855-548-9825 to learn more about the road to recovery. We can help you overcome your addiction today.

How Viibryd (Vilazodone) Affects The Brain And Body

As previously mentioned, Viibryd is an antidepressant that works by altering neurochemicals in the brain, specifically serotonin. Exactly how antidepressants work in this category are not fully known, but they have shown to improve your mood, sleep, appetite and energy levels, thereby restoring your interest in life.

This prescription can cause side effects in patients, some serious, so it’s important to report all physical or mental changes to your doctor. By working with your doctor, you can decide if this is the best medication to treat your depression.

Half-Life Of Viibryd (Vilazodone)

The half-life of any medication is the amount of time it stays in your system where it hits half of its effectiveness. The half-life of vilazodone is on the longer side at 25 hours.

As mentioned, do not abruptly stop taking vilazodone without the assistance from your doctor because of the risk of side effects from withdrawal. Your doctor can help you off the medication safely.

Factors That Influence How Long Viibryd (Vilazodone) Stays In Your System

There are a few variables which affect how long Viibryd stays in your system, like how long you have been taking the prescription, your dosage and other medications you are taking.

Other factors that may influence how long the prescription stays in your system are:

  • Age
  • Sex
  • Body Mass
  • Genetics
  • Food Intake
  • Metabolic Rate
  • Liver Function

If you’re unsure about your factors influencing the length of time vilazodone will stay in your system, talk to your doctor for help in figuring that out.

How Long Does Viibryd (Vilazodone) Stay In Your Urine, Hair And Blood?

Vilazodone is not a medication that is typically tested for in urine, hair or blood, and there is no data to suggest the prescription causes any types of false positives in drug tests. If you are having a drug test performed, it’s always best to give a full list of medications you are currently taking and have recently taken as a precautionary measure.

Most of the vilazodone is metabolized by proteins and the liver, leaving only one percent eliminated through the urine. Regarding blood, Viibryd has been known to potentially cause bleeding problems and shouldn’t be taken with aspirin.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.