Learn about the process of detoxing and managing withdrawal from Tofranil.

Tofranil (Imipramine) is a medication used to treat those suffering from depression. Tofranil belongs to the tricyclic antidepressant class, meaning it works by balancing natural neurotransmitters such as norepinephrine in the brain. The medication is also used for the treatment of enuresis, which is typically known as nighttime bed-wetting in children.

Starting treatment with imipramine has the potential to improve one’s mood, sleep, appetite, and energy level while restoring one’s interest in daily living. Always follow your doctor’s prescription instructions carefully.

Tofranil’s common side effects include dry mouth, constipation, urinary retention, blurred vision, confusion, weight gain, sedation and changes in heart rate. Contact your doctor immediately if you experience serious side effects such as fever, sore throat, muscle spasms in the jaw, neck or back, shaking, or difficulty speaking.

Tofranil (Imipramine) Withdrawal and Detox

Those treating depression with imipramine should never abruptly stop their treatment, as it may cause uncomfortable or enhanced withdrawal symptoms. If you are no longer interested in continuing with Tofranil treatment, contact a doctor immediately to devise a safe plan to gradually reduce your imipramine dosage. This safety plan will help you reduce the likelihood and severity of symptoms that occur as the drug is cleansed from the body.

Common Tofranil (Imipramine) Withdrawal Symptoms

Common Tofranil withdrawal symptoms include nausea, headache, fatigue, general malaise, lack of coordination, crying spells, depersonalization, flu-like symptoms, a tendency to overreact, and sensory or sleep disturbances.

Tofranil (Imipramine) Withdrawal Timeline and Symptom Durations

Everyone experiences the withdrawal effects of Tofranil differently. Some patients may recover within a few weeks, while for others the cleansing process may take one or several months. Regardless of your individual timeline, help is always available to get you through your recovery. Contact your doctor if you have questions or concerns regarding your discontinuance of imipramine.

Remember, it is never recommended that you or your loved one stop your imipramine treatment cold turkey. By talking with your doctor and gradually lowering your dosage, you are more likely to avoid any extreme Tofranil withdrawal symptoms.

Managing Withdrawal Symptoms of Tofranil (Imipramine)

The best way to manage any Tofranil discontinuance symptoms is to participate in a medically monitored detox program or drug rehabilitation program. A medically safe environment will help you recognize potential imipramine withdrawal symptoms as well as provide support as you learn how to properly manage the end of your treatment.

Tofranil (Imipramine) Medications and Detox

It is always important to keep a list of all your medications including nonprescription drugs and herbal products to share with your doctor or pharmacist, as some of these may interact with Tofranil. Some medications that interact with imipramine are drugs for Parkinson’s disease, high blood pressure, and MAO inhibitors. Consult your doctor if you have any questions regarding how your current medications could potentially interact with Tofranil, or if you are taking other products that cause drowsiness including alcohol, cannabis, antihistamines, drugs for sleep or anxiety and narcotic pain relievers.

If you or a loved one is treated with Tofranil, it is important to safely cleanse your body from the medication at the end of treatment. It is advised to seek assistance from a medical professional for safe detoxification in a supervised setting. Even if you or your loved one is taking imipramine as prescribed, they may develop a psychological need for the medication. In this case, talk to your doctor about how to gradually reduce your dosage.

Detoxification programs are specific to the individual, so there is not a general program that exactly fits everyone’s needs. Seek a location and program that is suitable for you or your loved one’s specific needs to recover safely from Tofranil.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.