Side Effects, Interactions & Risks

Mixing alcohol and Surmontil (trimipramine) should only be done after consulting a medical professional. Alcohol can change the effects of Surmontil and increase the level and frequency of side effects. While mixing alcohol and Surmontil, you may experience confusion, drowsiness, irregular heartbeats, agitation, nausea, vision troubles, vomiting, muscle soreness and seizures. If you exhibit any of these symptoms, contact your doctor or local emergency center immediately. If your doctor says it is okay to mix these two substances and you still experience side effects, the dosage level of Surmontil may need some adjustments. Overall, it is not advised to drink alcohol while taking antidepressants like Surmontil.


Avoid taking these medications in conjunction with trimipramine therapy:

  • Anticholinergic agents (Atropine, Belladonna Alkaloids)
  • High blood pressure medications
  • Liver enzyme inhibitors (Cimetidine, Haloperidol)
  • Monoamine oxidase inhibitors (MAOIs)
  • Selective Serotonin Reuptake Inhibitors (SSRIs)
  • Seizure drugs
  • Antihistamines
  • Anxiolytics
  • Muscle relaxants
  • Cough medicine
  • Respiratory stimulants and nasal decongestants

Because Surmontil heightens the effects of alcohol, blackouts may occur when mixing the substances. If you experience any blackouts while on Surmontil, it is important that you get medical help immediately. You should also talk to your doctor about lowering your dosage amount or avoiding mixing the two substances altogether.

What Is Surmontil (Trimipramine)?

Surmontil is a prescription drug that is used in the treatment of major depression. Trimipramine works by stalling the reuptake of neurotransmitters (serotonin and norepinephrine) in the brain. This causes the body to produce more serotonin and norepinephrine, chemicals that are believed to have an effect on mood. Trimipramine is usually prescribed in pill form, starting with dosages of 25 to 50 mg. The dosage level is normally increased over the course of the first few months of treatment. Patients taking Surmontil normally report feeling a difference a few weeks after starting therapy. You should never increase the daily dosage of Surmontil unless directed by your doctor. Overdoses of trimipramine are particularly dangerous and can easily lead to death, especially when mixed with other medications.

Mixing Alcohol And Surmontil (Trimipramine)

It is generally advised to avoid mixing alcohol and Surmontil. One of the biggest issues in mixing the two drugs are the side effects. You may experience an increase in the severity of side effects, including drowsiness, fatigue, nausea, vomiting and seizures. If you experience any of these symptoms while taking Surmontil, contact your doctor immediately.

Summing Up Side Effects, Interactions and Blackouts of Mixing Alcohol And Surmontil (Trimipramine)

Mixing alcohol and Surmontil can cause many serious symptoms. Alcohol tends to heighten the severity of trimipramine side effects and should only be used after consulting with your doctor. While you may experience normal side effects like drowsiness, fatigue and nausea, mixing alcohol with Surmontil can also lead to blackouts and seizures.

There is also an increased risk of overdose associated with mixing the two substances, which can lead to death in some cases. Always consult with your doctor when using trimipramine, especially if you are taking other medications.

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Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.