Trimipramine (which is also known by the brand name Surmontil) is a medication most often used to treat depression and other mood disorders. Trimipramine belongs to a class of drugs known as tricyclic antidepressants. It works by restoring the balance of certain chemicals in the brain. Surmontil is also occasionally used to treat insomnia and anxiety disorder.
Trimipramine is known as a cumulative drug, which means it takes time for the drug to accumulate in your system. It might not work right away. While some people report feeling better within one to two weeks of taking Surmontil, it may take up to a full month to feel its full effects. It is very important to continue taking trimipramine to receive its full benefit, even if you’re feeling better.
While many people benefit from taking Surmontil, it can cause undesired side effects. Remember that your doctor feels that the advantages of the drug outweigh any risk of side effects. Compared to other drugs in its class, however, the side effects associated with trimipramine are relatively few. Some of the more common side effects can be easily managed with simple lifestyle changes. You can help combat dizziness and lightheadedness caused by Surmontil by rising slowly from a lying or sitting position. Constipation resulting from trimipramine usage can be treated by adding more fiber to your diet, drinking plenty of water and exercise. Relieve dry mouth caused by Surmontil by sucking on sugarless hard candies or ice, chewing sugarless gum, or drinking water. Other common side effects of trimipramine include:
- Changes in appetite or weight
- Stomach pain
- Weakness or tiredness
- Excitement or anxiety
- A headache
- Difficulty or frequent urination
- Changes in sex drive or ability
- Excessive sweating
- Ringing in the ears
- Pain, burning or tingling in the hands or feet
Trimipramine works to increase serotonin levels in the brain. In very rare cases, this can lead to a serious condition called serotonin syndrome/toxicity. Seek medical attention right away if you experience one or more of the following symptoms while taking Surmontil:
- Shivering and goosebumps
- A severe headache
- Agitation or restlessness
- Dilated pupils
- Changes in blood pressure
- Nausea and/or vomiting
- Unexplained fever
- Rapid heart rate
- Loss of muscle coordination or twitching muscles
- Heavy sweating
Trimipramine is not considered addictive in the most commonly recognized sense as overuse of Surmontil doesn’t produce euphoric highs or cravings for the drug when discontinued. Like most drugs in its class, it’s considered to be at low risk of addiction. Discontinuing the drug rapidly can lead to physical withdrawal symptoms, however.
You can experience withdrawal symptoms if you discontinue trimipramine rapidly or “cold turkey.” Those who have been at higher doses and/or on Surmontil for a longer period are much more likely to experience withdrawal than those who have been on a low dose for a short time. Doctors will usually recommend that you taper off trimipramine in a controlled manner to decrease the likelihood of feeling withdrawal symptoms. The most common symptoms of Surmontil withdrawal include dizziness, fatigue, irritability, headaches, insomnia, muscle pain and mood swings.
The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.