Sublimaze How Long Does It Stay in Your System?

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Sublimaze is a potent analgesic opioid that’s used for pain relief before, during, and immediately following surgery. Sublimaze has a rapid onset of several minutes and an average terminal elimination half-life of 219 minutes.

Because Sublimaze vacates the body quickly, its pain-relieving effects can wear off before its respiratory depressant effects. Close monitoring of the patient’s respiratory drive is essential to avoid potentially life-threatening complications.

Several factors can influence the patient’s metabolism of the drug. The most significant factors are the patient’s age and weight. Additional factors include liver and kidney health, physical status, and any other underlying health conditions that may affect the body’s ability to process the drug.

Sublimaze is an injectable liquid solution of fentanyl citrate. The typical dose of Sublimaze used during surgery when administered preoperatively ranges between 50 mcg to 100 mcg. Initial doses are typically administered between 30 to 60 minutes prior to surgery. A 100-mcg dose of Sublimaze is roughly equivalent to 75 mg of meperidine or 10 mg of morphine. When administered during invasive surgery, doses are titrated accordingly.
Sublimaze How Long Does It Stay in Your System?
Fentanyl-based drugs are both highly addictive and carry a high potential for overdose. For these reasons, Sublimaze is tightly regulated. Sublimaze should only be given by medical professionals specifically trained in the administration of intravenous anesthetics. Specialized knowledge is required to effectively and safely manage the respiratory depressant effects of powerful opioids during anesthesia and sedation. The initial treatment of Sublimaze should range between 50 mcg to 100 mcg for adults and can be as low as 2 to 3 mcg/kg in children ages 2 to 12.
Sublimaze itself is rarely taken recreationally outside of the hospital setting; however, fentanyl-based drugs are commonly mixed with other central nervous system depressants when taken recreationally. Recreational use of Sublimaze with other central nervous system depressants can lead to life-threatening side effects including severe respiratory depression.

Nitrous oxide has been reported to result in cardiovascular depression when administered with high doses of Sublimaze. Certain forms of anesthesia produce a higher risk for respiratory issues by blocking the activity of intercostal nerves. The use of tranquilizers with Sublimaze can significantly reduce pulmonary arterial pressure. This can lead to hypotension and the possibility of hypovolemia.

Sublimaze reduces the patient’s perception of pain by binding to opioid mu-receptors in the body that regulate pain response. By activating these receptors, Sublimaze begins reducing pain almost immediately when administered intravenously. Pain relief may continue for 30 to 60 minutes following a single intravenous dose.

When administered intramuscularly, the onset of action ranges from seven to eight minutes and can last for one to two hours. The respiratory depressant effects of the drug can last longer. Respiratory depression due to Sublimaze is the result of the brain stem’s diminished sensitivity to carbon dioxide stimulation.

In un-medicated individuals, the automatic urge to breathe is regulated by carbon dioxide levels in the body. By depressing the brain stem’s ability to sense carbon dioxide levels, respiration becomes decreased. Peak respiratory depressant effects are reached between 5 to 15 minutes following intravenous injection.

The terminal elimination half-life of Sublimaze is typically 219 minutes. The initial distribution of the drug takes place in approximately 1.7 minutes, followed by a redistribution at 13 minutes. Sublimaze is distributed at a volume of 4 L/kg.
Several factors influence the rate of distribution of Sublimaze as well as the potential for complications. The patient’s age, weight, kidney and liver health, overall physical status, and the type of medical procedure being performed all impact the drug’s rate of excretion.

Sublimaze is primarily metabolized by the liver. Impaired liver function can increase clearance times and lead to elevated blood plasma levels of the drug. Fluctuations in the patient’s pH levels can affect the drug’s distribution between plasma and the central nervous system.

As with most substances, Sublimaze can be tested for in the hair for up to 90 days following administration. Fentanyl-based drugs can typically be tested for in the blood for up to 12 hours, and in the urine between 8 and 24 hours.

Sublimaze has a high first pass clearance. When injected intravenously, approximately 75% of the drug is passed in the urine. The majority is in the form of metabolites, with only 10% being unaltered fentanyl citrate. 9% of the administered drug is passed through the feces in the form of metabolites.

If you or someone you know is struggling with an opioid misuse disorder, The Recovery Village is here to help. Contact us or call our toll-free hotline anytime, day or night, for more information. We can help you to take control of your health today.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.