Parnate Signs of Abuse, Symptoms & Side Effects
Parnate is notorious for its long list of contraindications, complications, and potentially fatal drug interactions. Individuals taking tranylcypromine will need to avoid foods and beverages containing tyramine. Tyramine is a nutrient found in many foods and alcoholic drinks. Red wine is particularly high in tyramine. Foods that contain high levels of tyramine include fermented cheese and meats. Tyramine is produced as a byproduct of the fermentation process.
Patients will also need to avoid medications that increase the expression of serotonin. Combining the effects of drugs like selective serotonin reuptake inhibitors (SSRIs) can result in a dangerous condition known as serotonin syndrome and lead to permanent psychosis if left untreated.
Several instances have been reported of patients taking up to 30 ten mg tablets of tranylcypromine daily. These individuals obtained prescriptions from multiple doctors to supply their habit. Some of these patients ended up in the emergency room with symptoms of agitation, confusion, and hallucinations. A condition called thrombocytopenic purpura, in which blood platelet counts become low was also noted in some cases.
When transitioning off tranylcypromine, patients may experience increased irritability, restlessness, diarrhea, muscle twitches, fatigue, and weakness. These symptoms can be mitigated by gradually reducing the dose over the course of weeks, months, or years depending. The length of the discontinuation phase depends on the current dose strength and duration of treatment. Patients who have been taking Parnate for several years will need to allow for a longer and more gradual discontinuation period.
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