Parnate Abuse Signs, Symptoms, and Side Effects
Parnate is notorious for its long list of contraindications, complications, and potentially fatal drug interactions. Individuals taking tranylcypromine will need to avoid foods and beverages containing tyramine. Tyramine is a nutrient found in many foods and alcoholic drinks. Red wine is particularly high in tyramine. Foods that contain high levels of tyramine include fermented cheese and meats. Tyramine is produced as a byproduct of the fermentation process.
Patients will also need to avoid medications that increase the expression of serotonin. Combining the effects of drugs like selective serotonin reuptake inhibitors (SSRIs) can result in a dangerous condition known as serotonin syndrome and lead to permanent psychosis if left untreated.
Several instances have been reported of patients taking up to 30 ten mg tablets of tranylcypromine daily. These individuals obtained prescriptions from multiple doctors to supply their habit. Some of these patients ended up in the emergency room with symptoms of agitation, confusion, and hallucinations. A condition called thrombocytopenic purpura, in which blood platelet counts become low was also noted in some cases.
When transitioning off tranylcypromine, patients may experience increased irritability, restlessness, diarrhea, muscle twitches, fatigue, and weakness. These symptoms can be mitigated by gradually reducing the dose over the course of weeks, months, or years depending. The length of the discontinuation phase depends on the current dose strength and duration of treatment. Patients who have been taking Parnate for several years will need to allow for a longer and more gradual discontinuation period.
Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.
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