How Long Does Morphabond Stay In Your System?

Morphabond ER is an extended-release version of morphine. This drug is a single-agent medication, meaning morphine is the only active ingredient. It’s similar to the morphine drug MS Contin. Morphabond ER is an extended-release drug, and it has certain features designed to lower the risk of misuse. Morphabond is made with something called SentryBond Technology. If someone tries to misuse the drug by crushing it or breaking it to use it intravenously or snorting it, it should maintain its extended-release property. Morphabond is intended to be prescribed for severe ongoing pain. This opioid medication is not for acute or breakthrough pain, and it should be taken on a regularly prescribed basis for continual treatment when alternative treatments aren’t effective or aren’t tolerated.

Along with only being available with a prescription, Morphabond ER is a Schedule II controlled substance. The DEA defines Schedule II drugs as having medical uses but also as having a high potential for misuse and dependence. Despite the misuse-deterrent properties of Morphabond, misuse and addiction are still possible as are with other opioids. If someone uses Morphabond without a valid prescription, it’s illegal.

Morphine is a powerful pain reliever, often given intravenously in hospital and clinical settings. Morphine alters how pain signals are sent, but it comes with risks and side effects as well. All opioids, including morphine, have a high misuse potential. Along with intravenous morphine and tablet drugs like Morphabond, it can also be given as an oral solution or a suppository in some cases. Morphine is a naturally-derived opioid, and it’s made from opium. Brand-names of morphine that are used medically and diverted for misuse include Kadian, MS-Contin, Oramorph SR and Roxanol.

When someone uses Morphabond, the morphine binds to opioid receptors, which are found throughout the body including in the gastrointestinal tract and the central nervous system. When the opioid receptor sites are activated, it also causes the central nervous system to slow down. A slowdown in the central nervous system can lead to drowsiness, dizziness, sedation, a loss of coordination, and nausea and vomiting. Respiration, heart rate and blood pressure can also be affected by Morphabond. Since Morphabond is an extended-release drug, when someone uses it, it gradually releases the medicine into their system over a period of anywhere from eight to 12 hours. Some people may experience a euphoric high when taking Morphabond as well because it can trigger a large release of dopamine. Dopamine is a neurotransmitter responsible for pleasurable feelings.

The half-life of a drug gives a measure of how long it might take for a dose to be eliminated from the system of the individual. The half-life of Morphabond is estimated to be anywhere from two to four hours. It usually takes around five half-lives for most people to eliminate a full dose of a drug. This would put the average estimated half-life of Morphabond at anywhere from ten to 20 hours. Over time Morphabond accumulates in the system of an individual so that there can be a steady state concentration of the drug for around-the-clock pain relief.

When someone is prescribed Morphabond, different factors can influence how long it will stay in their system. This is true of all drugs — it’s not exclusive to Morphabond. Some of the things that may influence how long Morphabond stays in your system include:

  • Age: If all other factors are similar, it typically takes older people longer to eliminate drugs like Morphabond from their system than younger people.
  • Dosage: The higher the dosage, the longer it can take someone to eliminate Morphabond.
  • Liver and kidney function: If someone has hepatic or renal function impairment, it may take longer for drugs to fully leave their system.
  • Metabolism: Generally, when someone has a faster metabolism, drugs will clear their system more rapidly.
  • How long someone has taken Morphabond: Morphabond is intended to accumulate in the system of the individual to provide around-the-clock pain relief, so if someone has been using it for a period of time, it may take longer for a dose to leave their system.
  • Other substances: If someone has used other medications, drugs or alcohol it can take longer for Morphabond to clear their system.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.