Fentora How Long Does It Stay in Your System?

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Fentora is a variation of sublingual fentanyl. Fentora is an opioid narcotic that’s prescribed to alleviate breakthrough pain in cancer patients. Fentora has a rapid onset of 15 to 30 minutes and an approximate elimination half-life of 22 hours.
Fentora How Long Does It Stay in Your System?
Fentora is contraindicated in non-opioid tolerant patients. To be considered opioid tolerant, opioid doses equivalent to 60 mg of morphine or 20 mg of oxycodone per day must be taken for at least a week. Use of Fentora by non-opioid tolerant individuals increases the risk of life-threatening respiratory depression and overdose.

Share with your doctor if you have a history of liver malfunction. Fentora is processed primarily by the liver, meaning a decreased liver function may lead to increased clearance times and the drug could reach toxic plasma levels.

Fentora treatment causes vasodilation of the peripheral vasculature. This can lead to orthostatic hypotension and syncope; in other words, the patient may experience a sudden drop in blood pressure upon sitting or standing from a horizontal position. This can cause a sudden drop in blood pressure that causes the patient to faint. Flushing of the skin, sweating, and red eyes may also occur.

Fentora distribution is tightly regulated by the Federal Drug Administration and is classified as a Schedule II substance. Fentora is highly addictive and has a high overdose potential. Several individuals have overdosed on an initial therapeutic dose of sublingual fentanyl.

Fentora is part of the Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) Access program. The program is designed to reduce the occurrences of overdose and serious complications due to medical errors. It also seeks to address the prevalence of opioid substance misuse. Patients must be enrolled in the TIRF REMS Access program before they are considered eligible for treatment with Fentora.

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Fentora is commonly administered with other longer-acting opioids like morphine, oxycodone, or hydrocodone. These gradual-onset medications provide around-the-clock pain relief for cancer patients. Fentora is taken only when episodes of breakthrough pain occur.

Sublingual opioids such as Fentora may be taken recreationally in conjunction with benzodiazepines and other sedative/hypnotics. Taking Fentora alongside these substances greatly increases the risk of overdose, coma, and death.

Fentora achieves its pain-relieving effects by binding to opioid mu-receptors in the body. By binding to them, the opioid receptors become activated to reduce the patient’s perception of pain. In addition to pain reduction and respiratory depression, Fentora can cause a decreased level of consciousness.

In the event of an overdose, the patient’s condition can deteriorate rapidly to the patient becoming unresponsive. If left untreated the patient may become hypercapnic, which is a potentially fatal condition of carbon dioxide toxicity due to inadequate breathing. Pinpointed pupils are another common sign of opioid overdose; however, if the individual becomes severely hypoxic due to inhibited respiratory drive, pupils may become maximally dilated.

The median terminal elimination half-life of Fentora is 22 hours following sublingual administration. Peak effects of the drug are reached in as early as 15 minutes and may last several hours. Fentora’s half-life is slightly longer than the half-life of the intravenous version of the drug, which is approximately 18 hours from the time of injection.
Plasma concentrations of Fentora progressively decline through the uptake of the drug in the tissues and conversion in the liver. Fentora is metabolized primarily in the liver as well as the intestinal lining. Elderly patients age 65 or older report higher frequencies of adverse side effects due to reduced liver function. Such symptoms include constipation, vomiting, and abdominal pain. Respiratory depression is the primary risk for geriatric patients. Fentanyl is substantially secreted by the kidney. Patients with impaired renal function are at an increased risk for opioid toxicity when taking Fentora.
Fentora is mainly eliminated through urine. Less than seven percent of buccal fentanyl is eliminated unchanged in the urine. The rest is excreted in the urine as metabolites after being processed by the liver and kidneys. An insignificant percentage of Fentora is excreted unchanged in the feces. Minimal metabolites are excreted in the feces.

Following sublingual administration of Fentora, the drug is readily absorbed by the body. Fentora has an absolute bioavailability of 65%. Approximately 50% of the drug is absorbed transmucosally and becomes systemically available within 15 to 30 minutes of administration. The remaining half of the dose is absorbed over a longer period in the gastrointestinal tract.

If you or someone you know is struggling with opioid misuse, The Recovery Village is available to help. Visit us online at www.TheRecoveryVillage.com or call our hotline anytime, day or night, at 855-548-9825 for more information. We can help you overcome your addiction today.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.