How Long Does Diastat Stay in Your System?

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With prescription drugs, there are quite a few reasons a person might want to know how long it stays in their system. One reason is in case they have to undergo drug testing for any reason. Another reason is because of the risk of overdose that can occur with certain prescription drugs. People may also wonder if they’re physically dependent on a drug, how long it would be before withdrawal symptoms begin. All are relevant questions, which is why people wonder how long Diastat stays in your system.

Diastat is a brand name version of the benzodiazepine diazepam. Benzodiazepines are a class of drugs that act as central nervous system depressants. As a result, these drugs calm down certain brain activity. This can help alleviate symptoms of anxiety and panic disorder. Benzodiazepines can be classified based on their onset of action and their elimination half-time. With drugs that start working quickly, there is a higher addiction risk potential. If a drug has a rapid onset of action, people have to be especially careful of the risk of misuse and addiction that can occur. This isn’t true with just benzodiazepines. It’s the case with all drug classes. Drugs with faster action times tend to be the most addictive. Drugs that stay in the system for long periods of time can provide more therapeutic relief over time. However, they can also accumulate in the system of the person using it.

Diastat is used specifically as a treatment for breakthrough seizures. This means it’s for people who are on a daily anti-seizure medication and who experience a seizure anyway. Diastat isn’t a long-term daily treatment, and it can be addictive. Diastat is available in a gel form administered rectally when someone is experiencing a seizure. Diastat is given rectally because it is absorbed faster, which is important when dealing with potentially life-threatening cluster or breakthrough seizures. After taking Diastat rectally, seizures may stop within 15 minutes. The medication will keep working beyond that, however. Peak concentrations of Diastat usually occur in the bloodstream within 1.5 hours, but the effects of Diastat can continue for nearly two days. People who are prescribed Diastat are instructed to use it no more than once in a five-day period and no more than five times in a single month.

Diastat Addiction and Abuse
The mean elimination half-life of diazepam, the active ingredient in Diastat, is 46 hours to 71 hours. Diastat’s activity is the result of one major active metabolite and two minor metabolites. In young, healthy adults, the elimination half-life of diazepam can start at around 15 hours. The half-life goes up the older someone is. For example, if a healthy, elderly adult took it, the half-life of diazepam could be as much as 100 hours. So, what does this all mean? How long does Diastat stay in your system?

Diastat can stay in your system for up to a week after it’s used therapeutically. If someone chronically uses Diastat or uses large doses, the detection window can be significantly longer. In a urine screen, the use of a benzodiazepine like Diastat could be anywhere from four to six weeks. Overall in comparison, Diastat is a long-acting benzodiazepine. This can also mean withdrawal symptoms take longer to begin than with a shorter-acting benzo.

The struggle with benzodiazepines or other substances doesn’t have to be insurmountable. Contact us at The Recovery Village to see how a sustainable recovery is possible.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.