It can take up to two days for Conzip to exit the body entirely. Urine tests may detect Conzip for up to two days following the time of last dose. Saliva and blood screenings may test positive for Conzip for up to 24 hours.
Conzip is an extended-release formula of tramadol hydrochloride. Conzip is prescribed for the treatment of moderate to severe pain and is designed for 24-hour pain relief.

Common side effects of Conzip use include respiratory depression, lethargy, fatigue, drowsiness, somnolence, dizziness, nausea, vomiting, constipation, excessive sweating and itchiness. The itchiness caused by Conzip does not seem to be the result of a histamine release as is the case with morphine and other synthetic opioids. Low blood pressure upon standing may also be experienced.

Conzip comes in the 100 mg, 200 mg, and 300 mg capsules. They are designed to release a percentage of the drug immediately upon ingestion, and then gradually release the remainder of the drug over an extended period. The 100 mg capsules release 25 mg immediately, while the 200 mg and 300 mg capsules release 50 mg immediately upon ingestion.

Conzip is a Schedule IV controlled substance in the US under the regulation of the Federal Drug Administration (FDA). Australia also classifies Conzip as a Schedule IV drug, meaning that it is illegal to possess it without a prescription. Conzip is treated similarly in the UK and Sweden.
Conzip How Long Does It Stay In Your System?
In the medical setting, drugs containing tramadol are commonly combined with acetaminophen. The concomitant use of acetaminophen and tramadol increases tramadol’s pain-relieving effects.

When used recreationally, Conzip is commonly mixed with other central nervous system depressants. The combined use of Conzip with other central nervous system depressants can greatly increase the risk of life-threatening complications. The primary risk factor of Conzip use is severe respiratory depression.

Conzip should not be mixed with other opioids, benzodiazepines, non-benzodiazepine sedative/hypnotics, tranquilizers, muscle relaxants or alcohol. Conzip may conflict with these substances and can lead to extended clearance times and elevated plasma concentrations. This increases the risk of toxicity and overdose.

Conzip should not be mixed with serotonergic drugs, such as those used to treat depression. These include selective serotonin reuptake inhibitors (SSRIs) and tricyclics. The combined use of serotonergic medications with Conzip can result in a dangerous condition of serotonin overload called serotonin syndrome. Serotonin syndrome can result in psychosis and death in severe cases.

Conzip achieves its pain-relieving effects by activating opioid receptors in the body and inhibiting the reuptake of the neurotransmitters norepinephrine and serotonin. By inhibiting the reuptake of norepinephrine and serotonin, Conzip increases their activity in the brain.

Conzip is roughly one-tenth as powerful as equivalent doses of morphine and is equal in potency to codeine and pethidine. When ingested orally, Conzip begins to take effect in about an hour.

The total elimination half-life of Conzip is between ten and 11 hours. Steady-state plasma concentrations are typically reached within four days of once-daily dosing.
Several factors influence the clearance rate of Conzip and its metabolites from the body. These include the patient’s age, weight, size, body fat percentage, overall health, genetics, opioid tolerance, frequency of use, and kidney and liver function.

Conzip is primarily metabolized by the liver, and its metabolites are eliminated by the kidneys. Impaired function of these organs can greatly extend clearance rates. Patients with a history of hepatic or renal failure will likely require lower doses of the drug to avoid complications related to elevated opioid plasma concentrations.

Age can be a factor due to the overall slower metabolic rates that tend to characterize elderly populations. Smaller patients typically require lower doses of Conzip to achieve the desired pain-relieving effects.

Taking certain substances with Conzip can extend clearance rates. Carbamazepine increases Conzip metabolism, leading to faster elimination times and a reduction in pain-relieving effects. Ketoconazole, erythromycin, rifampin and St. John’s Wort may also alter tramadol exposure.

As with nearly all opioids, Conzip may be detected in hair follicle tests for up to 90 days following the time of last dose. Urine screenings may detect Conzip for up to 40 hours, and saliva and blood samples can test positive for up to 24 hours following the time of last dose.

If you or someone you love is struggling with opioid dependence, The Recovery Village is available to answer any questions you may have. Visit them online at or call them toll-free at 855-548-9825 to learn more about the road to recovery.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.